Vitamin K2 is a fat-soluble vitamin that activates key proteins responsible for calcium regulation. It directs calcium into bones via osteocalcin and prevents its deposition in arteries via Matrix Gla Protein (MGP). This dual action is highly relevant to healthspan by simultaneously supporting skeletal integrity and mitigating vascular calcification, a key driver of age-related cardiovascular disease.
Verdict
A high-value supplement for cardiovascular and bone health.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$5 - $20
Protocol
- Daily supplementation of 100-200 mcg of the MK-7 form is a common protocol.
- Some protocols utilize higher doses of the MK-4 form, such as 1.5-5 mg daily.
Flags
- Interferes with anticoagulant drugs like Warfarin (Coumadin); consult a physician before use.
- MK-7 has a longer half-life than MK-4, allowing for more stable, once-daily dosing.
- Often combined with Vitamin D3, as they work synergistically for calcium metabolism.