Meta Information
ID:vitamin-k2
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/intervention/warfarin
Target name:
Warfarin (Coumadin)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin K directly opposes the anticoagulant effect of warfarin by promoting the synthesis of clotting factors, which can lead to therapeutic failure and increased risk of blood clots.
Actionable advice:
Do not take Vitamin K2 supplements while on warfarin unless specifically instructed and closely monitored by your prescribing physician.
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Dietary Fat
Severity:
major
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
As a fat-soluble vitamin, Vitamin K2 requires dietary fats for proper absorption from the small intestine into the bloodstream.
Actionable advice:
Always take Vitamin K2 with a meal that contains some healthy fat (e.g., olive oil, avocado, nuts).
Target id:
/class/bile-acid-sequestrants
Target name:
Bile Acid Sequestrants (e.g., Cholestyramine)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
1
Description:
These medications bind to bile acids in the gut, which prevents the proper absorption of fat-soluble vitamins like Vitamin K2.
Actionable advice:
Take Vitamin K2 at least 1 hour before or 4 hours after taking bile acid sequestrants.
Target id:
/intervention/orlistat
Target name:
Orlistat (Xenical, Alli)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Orlistat blocks the absorption of dietary fat, which is necessary to absorb fat-soluble vitamins like Vitamin K2.
Actionable advice:
Separate Vitamin K2 doses from Orlistat by at least 2 hours.
Target id:
/biomarker/inr
Target name:
INR (Prothrombin Time)
Severity:
major
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin K2 supplementation directly opposes the effect of warfarin, causing a lower INR reading which indicates a reduced level of anticoagulation and increased clotting risk.
Actionable advice:
Do not take Vitamin K2 if you are monitoring INR for warfarin therapy, unless under strict medical supervision.
Target id:
/intervention/vitamin_d3_systemic_healthspan
Target name:
Vitamin D3
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Vitamin D promotes the synthesis of proteins (e.g., osteocalcin, MGP) that Vitamin K2 then activates to properly regulate calcium placement in the body, enhancing bone and cardiovascular health.
Actionable advice:
Take Vitamin K2 and Vitamin D3 together with a fatty meal for optimal effect.
Target id:
/intervention/vitamin-e
Target name:
Vitamin E (High Doses)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
High supplemental doses of Vitamin E (>800 IU/day) can antagonize the effects of Vitamin K, particularly its role in blood clotting, and may impair its absorption.
Actionable advice:
Avoid taking very high doses of Vitamin E with Vitamin K2 unless directed by a physician.
Target id:
/intervention/vitamin-a
Target name:
Vitamin A (High Doses)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
High supplemental doses of Vitamin A (>10,000 IU/day) can compete with Vitamin K for intestinal absorption, potentially leading to reduced Vitamin K status.
Actionable advice:
Avoid taking high doses of Vitamin A with Vitamin K2 unless medically supervised.
Target id:
/class/antibiotics-long-term
Target name:
Antibiotics (Long-term Use)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Long-term use of broad-spectrum antibiotics can reduce the gut bacteria that produce some forms of Vitamin K2 (menaquinones), potentially lowering overall vitamin K status.
Actionable advice:
If on long-term antibiotics, ensure consistent intake of Vitamin K2 from supplements or food.
Target id:
/condition/hepatic-impairment
Target name:
Severe Liver Disease
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The liver is the primary site for synthesizing vitamin K-dependent clotting factors; in severe liver disease, this function is compromised, and response to vitamin K is unpredictable.
Actionable advice:
Consult a physician before using Vitamin K2 if you have severe liver disease.
Target id:
/intervention/magnesium
Target name:
Magnesium
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Magnesium is an essential cofactor for the conversion and activation of Vitamin D, which in turn works synergistically with Vitamin K2 for calcium regulation.
Actionable advice:
Consider taking magnesium in the same supplement regimen as Vitamin D and K2.
Target id:
/condition/renal-impairment
Target name:
Chronic Kidney Disease
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin K2 may help prevent vascular calcification, a common and serious complication in chronic kidney disease, by activating matrix Gla protein (MGP).
Actionable advice:
Discuss with your nephrologist; Vitamin K2 may be beneficial but requires coordination with other treatments.
Target id:
/intervention/vitamin-a
Target name:
Vitamin A (Physiological Doses)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Vitamins A, D, and K are all fat-soluble vitamins that work together to regulate gene expression and support bone and immune health at normal intake levels.
Actionable advice:
Ensure adequate, but not excessive, Vitamin A intake when supplementing with Vitamin K2.