Meta Information

ID:vitamin-k2

Name:Vitamin K2

Schema Version:1.5

Alternate Names

• Menaquinone
• MK-4
• MK-7

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

5

High Cost:

20

Cost Type:

monthly

Description:

Cost for daily over-the-counter MK-7 or MK-4 supplements.

Summary

Vitamin K2 is a fat-soluble vitamin that activates key proteins responsible for calcium regulation. It directs calcium into bones via osteocalcin and prevents its deposition in arteries via Matrix Gla Protein (MGP). This dual action is highly relevant to healthspan by simultaneously supporting skeletal integrity and mitigating vascular calcification, a key driver of age-related cardiovascular disease.

Purpose

Directs calcium into bones and away from arteries.

Card Summary

A fat-soluble vitamin that activates proteins to properly regulate calcium deposition, supporting bone density and cardiovascular health.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

7.2

Justification:

Crucial for calcium metabolism, potentially reducing arterial calcification and improving bone density.

Evidence

Grade:

B

Score:

7.5

Justification:

Strong observational data and some human RCTs support cardiovascular and bone benefits.

Safety

Score:

2.5

Justification:

Generally recognized as safe (GRAS) with no known toxicity at supplemental doses.

Flags

• Interferes with anticoagulant drugs like Warfarin (Coumadin); consult a physician before use.
• MK-7 has a longer half-life than MK-4, allowing for more stable, once-daily dosing.
• Often combined with Vitamin D3, as they work synergistically for calcium metabolism.

Verdict

A high-value supplement for cardiovascular and bone health.

Created

2026-04-23T21:06:01.128901Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Vitamin K2 is a fat-soluble vitamin that activates key proteins responsible for calcium regulation. It directs calcium into bones via osteocalcin and prevents its deposition in arteries via Matrix Gla...

Typical Protocol

• Daily supplementation of 100-200 mcg of the MK-7 form is a common protocol.
• Some protocols utilize higher doses of the MK-4 form, such as 1.5-5 mg daily.