Urolithin A

Urolithin A is a postbiotic compound produced by gut bacteria from dietary precursors like ellagitannins, found in pomegranates and berries. Its primary healthspan relevance stems from its ability to induce mitophagy, the process of clearing out old, dysfunctional mitochondria. By improving mitochondrial quality control, Urolithin A may enhance cellular energy production and muscle function, which typically decline with age.

Verdict

Promising for mitochondrial health and muscle function, pending more independent research.

Protocol

• Daily dosages typically range from 250mg to 1000mg, often taken with food.

Flags

• Individual gut microbiomes vary in their ability to produce Urolithin A from dietary precursors.
• Much of the human research is funded by the primary commercial producer.
• Long-term safety and efficacy data in humans is still limited.