Meta Information
ID:urolithin-a
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of Urolithin A supplementation during pregnancy has not been established through clinical research.
Actionable advice:
Avoid Urolithin A supplementation completely during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if Urolithin A or its metabolites are excreted into breast milk or what their effects on a nursing infant might be.
Actionable advice:
Avoid Urolithin A supplementation completely while breastfeeding.
Target id:
/class/ugt1a1-substrates
Target name:
UGT1A1 Substrates
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Urolithin A may inhibit the UGT1A1 enzyme, which is responsible for metabolizing certain drugs. This could increase the concentration and potential for side effects of medications like some statins (atorvastatin) or chemotherapy agents (irinotecan).
Actionable advice:
Consult a physician before use if taking medications metabolized by the UGT1A1 enzyme.
Target id:
/intervention/exercise
Target name:
Exercise
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Urolithin A promotes the clearing of damaged mitochondria (mitophagy), while exercise stimulates the creation of new, healthy mitochondria (biogenesis). This combination creates a powerful 'remove and replace' cycle for cellular and muscle health.
Actionable advice:
Combine regular Urolithin A supplementation with a consistent exercise routine for enhanced benefits.
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Urolithin A is metabolized by the liver via glucuronidation and sulfation. In cases of severe liver disease, its clearance may be impaired, although specific clinical data is lacking.
Actionable advice:
Consult a physician before using Urolithin A if you have significant liver disease.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
As a polyphenol metabolite, Urolithin A may have theoretical mild antiplatelet effects. While not clinically established, this could potentially increase bleeding risk when combined with blood-thinning medications.
Actionable advice:
Use with caution and monitor for any signs of increased bruising or bleeding if taking anticoagulant or antiplatelet drugs.
Target id:
/class/ampk-activators
Target name:
AMPK Activators
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Urolithin A's primary action of mitophagy is complementary to the effects of AMPK activators (like metformin or berberine), which also promote autophagy and mitochondrial biogenesis, potentially leading to synergistic effects on cellular rejuvenation.
Actionable advice:
Consider combining with AMPK activators for a potentially enhanced effect on mitochondrial health.
Target id:
/intervention/nmn_systemic_healthspan
Target name:
NMN (Nicotinamide Mononucleotide)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
By improving mitochondrial quality through mitophagy, Urolithin A may create a more efficient cellular environment for NAD+ precursors like NMN to support energy production and sirtuin activity.
Actionable advice:
Taking Urolithin A may improve the cellular machinery that utilizes NAD+ precursors.
Target id:
/intervention/nr
Target name:
Nicotinamide Riboside (NR)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
By clearing dysfunctional mitochondria, Urolithin A may enhance the cell's ability to effectively use NAD+ precursors like NR, leading to better support for cellular energy and repair pathways.
Actionable advice:
Taking Urolithin A may improve the cellular machinery that utilizes NAD+ precursors.
Target id:
/circadian/wake
Target name:
Waking Up
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
1
Description:
Taking Urolithin A in the morning may better align with the natural circadian rhythms of mitochondrial quality control processes, including mitophagy, potentially enhancing its biological effect.
Actionable advice:
Take your daily dose of Urolithin A in the morning.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking Urolithin A with food is not required for its absorption but may improve gastrointestinal tolerance for sensitive individuals.
Actionable advice:
Take with a meal if you experience any stomach discomfort, otherwise it can be taken on an empty stomach.
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The kidneys are involved in the clearance of Urolithin A metabolites. While no kidney toxicity has been reported, caution is warranted in individuals with severe renal impairment.
Actionable advice:
Consult a physician before use if you have severe kidney disease.
Target id:
/class/antibiotics-long-term
Target name:
Antibiotics (Long-term Use)
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
This interaction affects natural production, not the supplement. Long-term antibiotic use can destroy the gut bacteria that convert dietary precursors (ellagitannins) into Urolithin A, making supplementation a more reliable method to achieve consistent levels.
Actionable advice:
If on long-term antibiotics, be aware your natural production of Urolithin A is likely compromised.
Target id:
/dietary/ellagitannin-rich-foods
Target name:
Ellagitannin-Rich Foods (Pomegranates, Berries, Walnuts)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
While Urolithin A supplementation bypasses the need for dietary precursors, consuming ellagitannin-rich foods supports the gut microbiome responsible for its natural production, which may have other independent health benefits.
Actionable advice:
Continue to include pomegranates, berries, and walnuts in your diet for overall gut health.
Target id:
/class/immunosuppressants
Target name:
Immunosuppressants
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Urolithin A modulates mitochondrial function (mitophagy), a process critical for proper immune cell activity and memory. This could theoretically interfere with the intended action of immunosuppressant medications, though this is not clinically proven.
Actionable advice:
Consult your specialist before using Urolithin A if you are on immunosuppressive therapy.