Resveratrol is a polyphenol found in grapes and other plants, famed for its ability to activate sirtuins, particularly SIRT1. These proteins are crucial for cellular repair, metabolism, and stress resistance, leading to the hypothesis that resveratrol could mimic some effects of caloric restriction. However, its extremely poor bioavailability in humans has significantly hampered the translation of promising animal study results into clear healthspan benefits.
Verdict
Promising in theory, but lacks compelling human evidence for healthspan extension.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$20 - $60
Protocol
- Daily dosages typically range from 250 mg to 1,000 mg of trans-resveratrol.
Flags
- Very low bioavailability is a major challenge for efficacy.
- May interact with blood thinners (e.g., warfarin) and anti-platelet drugs.
- High doses (>1g) are often associated with gastrointestinal side effects.
- Most positive animal data used doses not achievable in humans through oral supplementation.
- May blunt some positive adaptations to exercise.