Meta Information

ID:resveratrol

Name:Resveratrol

Schema Version:1.5

Title

Resveratrol

Alternate Names

• trans-Resveratrol
• 3,5,4'-trihydroxy-trans-stilbene

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

20

High Cost:

60

Cost Type:

monthly

Description:

Cost for a 30-day supply of standard trans-resveratrol capsules.

Summary

Resveratrol is a polyphenol found in grapes and other plants, famed for its ability to activate sirtuins, particularly SIRT1. These proteins are crucial for cellular repair, metabolism, and stress resistance, leading to the hypothesis that resveratrol could mimic some effects of caloric restriction. However, its extremely poor bioavailability in humans has significantly hampered the translation of promising animal study results into clear healthspan benefits.

Purpose

A polyphenol that activates sirtuins to mimic caloric restriction.

Card Summary

A plant-derived polyphenol that activates sirtuin pathways, potentially mimicking some effects of caloric restriction to support cellular health and metabolism.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Strong animal data has not translated into significant healthspan benefits in human trials.

Evidence

Grade:

B

Score:

4.5

Justification:

Many human trials exist but show mixed, modest, or null results for healthspan endpoints.

Safety

Score:

3

Justification:

Generally safe, but can cause GI issues and interacts with blood-thinning medications.

Flags

• Very low bioavailability is a major challenge for efficacy.
• May interact with blood thinners (e.g., warfarin) and anti-platelet drugs.
• High doses (>1g) are often associated with gastrointestinal side effects.
• Most positive animal data used doses not achievable in humans through oral supplementation.
• May blunt some positive adaptations to exercise.

Verdict

Promising in theory, but lacks compelling human evidence for healthspan extension.

Created

2026-04-24T00:08:01.583701Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Resveratrol is a polyphenol found in grapes and other plants, famed for its ability to activate sirtuins, particularly SIRT1. These proteins are crucial for cellular repair, metabolism, and stress res...

Typical Protocol

• Daily dosages typically range from 250 mg to 1,000 mg of trans-resveratrol.