Meta Information
ID:resveratrol
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol exhibits antiplatelet activity, which can add to the effects of anticoagulant and antiplatelet medications (e.g., warfarin, clopidogrel, aspirin, NSAIDs), significantly increasing the risk of bleeding.
Actionable advice:
Avoid taking resveratrol with these medications unless specifically approved and monitored by your physician.
Target id:
/procedure/surgery
Target name:
Surgery (Elective)
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Due to its antiplatelet (blood-thinning) effects, resveratrol can increase the risk of excessive bleeding during and after surgical procedures.
Actionable advice:
Discontinue resveratrol at least 2 weeks prior to any scheduled surgery and inform your surgeon.
Target id:
/condition/bleeding-disorders
Target name:
Bleeding Disorders
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol's antiplatelet activity can exacerbate bleeding tendencies in individuals with pre-existing conditions like hemophilia or von Willebrand disease.
Actionable advice:
Avoid resveratrol completely if you have any type of bleeding disorder.
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Fat
Severity:
major
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Resveratrol is a fat-soluble polyphenol with very low bioavailability when taken on an empty stomach. Co-administration with dietary fat significantly enhances its absorption.
Actionable advice:
Always take resveratrol with a meal that contains a source of healthy fat (e.g., olive oil, avocado, nuts).
Target id:
/class/cyp3a4-substrates
Target name:
CYP3A4 Substrates
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol can inhibit the CYP3A4 enzyme, which is responsible for metabolizing many common drugs. This can increase the concentration and risk of side effects from medications like certain statins (atorvastatin, simvastatin), calcium channel blockers, and benzodiazepines.
Actionable advice:
Consult a pharmacist or physician to check for interactions if taking any prescription medications.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol inhibits the CYP2C9 enzyme, potentially increasing levels and toxicity of drugs like warfarin, phenytoin, and some NSAIDs (e.g., ibuprofen, celecoxib).
Actionable advice:
Exercise caution and consult a healthcare provider if taking medications metabolized by CYP2C9.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol may lower blood glucose levels. When combined with diabetes medications (e.g., metformin, sulfonylureas, insulin), this can create an additive effect and increase the risk of hypoglycemia (dangerously low blood sugar).
Actionable advice:
Monitor blood glucose levels very closely if combining resveratrol with diabetes medications and consult your doctor.
Target id:
/condition/hormone-sensitive-cancers
Target name:
Hormone-Sensitive Conditions (e.g., Breast Cancer)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol has complex phytoestrogenic properties, meaning it can mimic estrogen in some tissues. This could theoretically interfere with hormone balance or affect the growth of hormone-sensitive cancers (breast, uterine, ovarian).
Actionable advice:
Avoid resveratrol if you have a history of hormone-sensitive cancers unless cleared by your oncologist.
Target id:
/intervention/quercetin
Target name:
Quercetin
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Quercetin inhibits the sulfation and glucuronidation of resveratrol in the intestines and liver, two primary pathways that break it down. This action significantly increases resveratrol's bioavailability and circulating levels.
Actionable advice:
Consider taking quercetin concurrently with resveratrol to enhance its absorption and potential benefits.
Target id:
/intervention/piperine
Target name:
Piperine (Black Pepper Extract)
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Piperine is a well-known inhibitor of glucuronidation, a key metabolic process that rapidly inactivates and eliminates resveratrol from the body. Taking them together increases resveratrol's bioavailability.
Actionable advice:
Take resveratrol with piperine to improve its absorption and effectiveness.
Target id:
/class/herbal-anticoagulants
Target name:
Herbal Anticoagulants/Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining resveratrol with other supplements that have blood-thinning properties (e.g., ginkgo biloba, garlic, high-dose fish oil, vitamin E) can have an additive effect and increase the overall risk of bleeding or bruising.
Actionable advice:
Use extreme caution and preferably avoid combining resveratrol with other supplements that affect blood clotting.
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol is extensively metabolized by the liver. Impaired liver function could lead to higher-than-expected drug levels and an increased risk of adverse effects.
Actionable advice:
Use with caution and only under medical supervision if you have liver disease.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is insufficient safety data on the use of resveratrol supplements during pregnancy. Its potential hormonal and antiplatelet effects pose a theoretical risk.
Actionable advice:
Avoid resveratrol supplements completely during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if resveratrol or its metabolites pass into breast milk or what their effects might be on a nursing infant.
Actionable advice:
Avoid resveratrol supplements completely while breastfeeding.
Target id:
/class/cyp1a2-substrates
Target name:
CYP1A2 Substrates
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol may weakly inhibit the CYP1A2 enzyme, which could slightly slow the metabolism and increase the effects of substances like caffeine and theophylline.
Actionable advice:
Be mindful of potentially increased effects (e.g., jitters from caffeine) when taking high doses of resveratrol.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol may have a mild blood pressure-lowering effect through vasodilation. This could be additive with antihypertensive drugs, potentially causing dizziness or hypotension.
Actionable advice:
Monitor your blood pressure if you are combining resveratrol with blood pressure-lowering medications.
Target id:
/class/iron-supplements
Target name:
Iron Supplements
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
As a polyphenol, resveratrol can bind to (chelate) non-heme iron in the gut, forming a complex that is poorly absorbed and reducing the efficacy of the iron supplement.
Actionable advice:
Separate resveratrol and iron supplement doses by at least 2 hours.
Target id:
/class/p-glycoprotein-substrates
Target name:
P-glycoprotein Substrates
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Resveratrol may inhibit the P-glycoprotein (P-gp) efflux pump in the intestines, which could increase the absorption and concentration of certain drugs like digoxin or fexofenadine.
Actionable advice:
Be aware of this potential interaction if taking P-gp substrate medications and monitor for increased side effects.