Quercetin is a plant flavonoid with antioxidant and anti-inflammatory properties. It is primarily investigated in a healthspan context for its potential as a senolytic, an agent that selectively induces apoptosis in senescent cells. By reducing the burden of these pro-inflammatory, non-dividing cells, quercetin may mitigate a key driver of age-related tissue dysfunction.
Verdict
A promising experimental senolytic, but await more robust human data.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$15 - $40
Protocol
- Take 500-1000 mg daily, often combined with bromelain or a phytosome for enhanced absorption.
Flags
- Poor bioavailability; often formulated with bromelain, vitamin C, or lipids (phytosome) to improve absorption.
- May interact with blood thinners (e.g., warfarin) and certain antibiotics (quinolones).
- High doses may pose a risk for individuals with pre-existing kidney disease.