Meta Information
ID:quercetin
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Fat
Severity:
moderate
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Quercetin is a fat-soluble flavonoid, and its absorption from the gut is significantly increased when consumed with dietary fats.
Actionable advice:
Take quercetin with a meal that includes healthy fats like olive oil, avocado, or nuts to improve absorption.
Target id:
/class/immunosuppressants
Target name:
Calcineurin Inhibitors (e.g., Cyclosporine, Tacrolimus)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Quercetin inhibits CYP3A4 and P-glycoprotein, enzymes critical for metabolizing these drugs, which can dangerously increase their blood levels and risk of toxicity.
Actionable advice:
Avoid completely if taking calcineurin inhibitors like cyclosporine or tacrolimus.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets (e.g., Warfarin, Clopidogrel)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Quercetin may inhibit platelet aggregation, potentially adding to the effects of blood-thinning medications and increasing the risk of bleeding.
Actionable advice:
Consult your physician before using if you take any blood-thinning medications or have a bleeding disorder.
Target id:
/class/cyp3a4-substrates
Target name:
Drugs Metabolized by CYP3A4
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Quercetin is a moderate inhibitor of the CYP3A4 enzyme, which can slow the breakdown and increase the concentration of many common medications.
Actionable advice:
Consult your pharmacist or doctor to check for interactions, as quercetin can increase levels of many medications.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9 (e.g., Warfarin, some NSAIDs)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Quercetin can inhibit the CYP2C9 enzyme, potentially increasing the levels and effects of drugs metabolized through this pathway.
Actionable advice:
Use with caution and consult a healthcare professional if taking medications metabolized by CYP2C9.
Target id:
/class/p-glycoprotein-substrates
Target name:
P-glycoprotein Substrates (e.g., Digoxin, Fexofenadine)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Quercetin inhibits the P-glycoprotein (P-gp) efflux pump, which can increase the absorption and blood levels of certain drugs, enhancing their effects and side effects.
Actionable advice:
Avoid concurrent use with P-gp substrate drugs unless cleared by your doctor.
Target id:
/condition/renal-impairment
Target name:
Kidney Disease
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Very high intravenous doses of quercetin have been linked to kidney damage in rare cases; caution is advised for individuals with pre-existing renal impairment.
Actionable advice:
Consult your doctor before use if you have any form of kidney disease.
Target id:
/procedure/major-surgery
Target name:
Scheduled Surgery
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Due to its potential antiplatelet (blood-thinning) effects, quercetin may increase the risk of bleeding during and after surgical procedures.
Actionable advice:
Discontinue quercetin at least 2 weeks prior to any scheduled surgery.
Target id:
/intervention/iron-bisglycinate
Target name:
Iron Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Quercetin is an iron chelator, meaning it can bind to iron in the digestive tract and significantly reduce its absorption.
Actionable advice:
Separate doses of quercetin and iron supplements by at least 2 hours.
Target id:
/class/chemotherapy-radiation
Target name:
Chemotherapy & Radiation
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
The antioxidant properties of quercetin could theoretically interfere with the effectiveness of cancer therapies that rely on oxidative stress to destroy malignant cells.
Actionable advice:
Avoid completely during active cancer treatment unless specifically directed by your oncologist.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is insufficient safety data to establish the effects of quercetin supplementation during pregnancy.
Actionable advice:
Avoid quercetin supplements during pregnancy due to a lack of safety information.
Target id:
/condition/lactation
Target name:
Breastfeeding
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is not known if quercetin passes into breast milk or what its effects might be on a nursing infant.
Actionable advice:
Avoid quercetin supplements while breastfeeding due to a lack of safety information.
Target id:
/intervention/dasatinib
Target name:
Dasatinib (Senolytic Therapy)
Severity:
major
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Quercetin is intentionally combined with Dasatinib in specific protocols to act as a senolytic agent, synergistically helping to clear senescent cells.
Actionable advice:
Take at the same time as Dasatinib only when used as part of a medically supervised senolytic protocol.
Target id:
/intervention/zinc
Target name:
Zinc
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Quercetin acts as a zinc ionophore, a molecule that helps transport zinc ions across cell membranes, potentially enhancing zinc's intracellular activity.
Actionable advice:
Take at the same time as zinc to potentially increase cellular zinc levels.
Target id:
/intervention/vitamin_c_systemic_healthspan
Target name:
Vitamin C
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Vitamin C can help regenerate oxidized quercetin back to its active form, potentially enhancing its antioxidant capacity and bioavailability.
Actionable advice:
Consider taking with Vitamin C to support quercetin's antioxidant activity.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Quercetin may have mild blood pressure-lowering effects, which could be additive with antihypertensive drugs, potentially leading to hypotension.
Actionable advice:
Monitor blood pressure if combining with blood pressure medication.
Target id:
/class/chelating-antibiotics
Target name:
Quinolone Antibiotics (e.g., Ciprofloxacin)
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Quercetin may interfere with the action of quinolone antibiotics through several proposed mechanisms, including enzyme inhibition.
Actionable advice:
Avoid taking quercetin at the same time as quinolone antibiotics.
Target id:
/intervention/bromelain
Target name:
Bromelain
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
The enzyme bromelain is thought to enhance the absorption of quercetin in the small intestine, though evidence is limited.
Actionable advice:
Can be taken with bromelain to potentially improve absorption.
Target id:
/intervention/fisetin
Target name:
Fisetin
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
As both are flavonoid senolytics, taking them together may produce additive or synergistic effects on cellular senescence and antioxidant pathways.
Actionable advice:
Can be taken with fisetin for potentially complementary effects.