Pterostilbene is a polyphenol structurally similar to resveratrol but with significantly higher bioavailability. It is believed to support healthspan by activating sirtuins, reducing oxidative stress, and modulating inflammatory pathways. Its potential benefits for cognitive function and metabolic health are areas of active research, though human data remains limited.
Verdict
An experimental resveratrol alternative with limited human data and cholesterol concerns.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
C
MONTHLY COST
$15 - $35
Protocol
- Typical daily doses range from 50mg to 150mg, often taken with a fat source to improve absorption.
Flags
- Caution: Some human studies show pterostilbene can significantly increase LDL cholesterol.
- May interact with anticoagulant and anti-diabetic medications due to potential effects on blood.