Meta Information

ID:pterostilbene

Name:Pterostilbene

Schema Version:1.5

Alternate Names

• Dimethylresveratrol
• 3,5-dimethoxy-4'-hydroxystilbene

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

15

High Cost:

35

Cost Type:

monthly

Description:

Cost for a typical one-month supply of 50-150mg daily capsules.

Summary

Pterostilbene is a polyphenol structurally similar to resveratrol but with significantly higher bioavailability. It is believed to support healthspan by activating sirtuins, reducing oxidative stress, and modulating inflammatory pathways. Its potential benefits for cognitive function and metabolic health are areas of active research, though human data remains limited.

Purpose

A resveratrol analog for sirtuin activation and antioxidant support.

Card Summary

A more bioavailable analog of resveratrol, pterostilbene is studied for its potential to activate sirtuins, reduce oxidative stress, and support metabolic health.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Promising animal data but very limited human trials for longevity-relevant endpoints.

Evidence

Grade:

C

Score:

3.8

Justification:

Primarily supported by animal and in-vitro studies; human longevity data is sparse.

Safety

Score:

3.8

Justification:

Generally well-tolerated but may unexpectedly increase LDL cholesterol in some individuals.

Flags

• Caution: Some human studies show pterostilbene can significantly increase LDL cholesterol.
• May interact with anticoagulant and anti-diabetic medications due to potential effects on blood.

Verdict

An experimental resveratrol alternative with limited human data and cholesterol concerns.

Created

2026-04-25T00:01:43.021164Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Pterostilbene is a polyphenol structurally similar to resveratrol but with significantly higher bioavailability. It is believed to support healthspan by activating sirtuins, reducing oxidative stress,...

Typical Protocol

• Typical daily doses range from 50mg to 150mg, often taken with a fat source to improve absorption.