Meta Information
ID:pterostilbene
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/dietary/high-fat-meal
Target name:
Meal Containing Fat
Severity:
moderate
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Pterostilbene is a fat-soluble compound, and its absorption from the gut is significantly improved when consumed with dietary fats.
Actionable advice:
Take pterostilbene with a meal that includes a source of healthy fat, like olive oil, avocado, or nuts.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene can lower blood sugar, and taking it with other diabetes medications (like metformin, insulin, or SGLT2 inhibitors) may increase the risk of hypoglycemia (low blood sugar).
Actionable advice:
Monitor blood glucose closely and consult your doctor if combining with any diabetes medication.
Target id:
/class/glucose-lowering-supplements
Target name:
Glucose-Lowering Supplements
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining pterostilbene with other supplements that lower blood sugar, such as berberine or alpha-lipoic acid, can have an additive effect and increase the risk of hypoglycemia.
Actionable advice:
Use caution and monitor for symptoms of low blood sugar when combining with other glucose-lowering supplements.
Target id:
/class/statins
Target name:
Statins (HMG-CoA Reductase Inhibitors)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Some human studies show pterostilbene can increase LDL cholesterol, which may counteract the primary goal of statin therapy. Close monitoring is required.
Actionable advice:
Monitor your lipid panel (especially LDL-C and ApoB) regularly if combining pterostilbene with a statin.
Target id:
/biomarker/lipid-panel
Target name:
Lipid Panel
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene, particularly at higher doses, has been observed in some clinical trials to increase levels of LDL cholesterol (LDL-C).
Actionable advice:
Regularly monitor your lipid panel, including LDL-C and ApoB, when taking pterostilbene.
Target id:
/class/cyp1a2-substrates
Target name:
CYP1A2 Substrates
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene inhibits the CYP1A2 enzyme, which can slow the breakdown of certain medications, potentially increasing their concentration and risk of side effects.
Actionable advice:
Consult your doctor before combining with medications metabolized by CYP1A2, such as caffeine, theophylline, or clozapine.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene may inhibit the CYP2C9 enzyme, potentially increasing levels and effects of drugs like warfarin, phenytoin, or certain NSAIDs.
Actionable advice:
Use with caution and consult a healthcare provider if taking medications metabolized by CYP2C9, especially anticoagulants.
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene is metabolized by the liver, and individuals with impaired liver function may have difficulty clearing it, potentially increasing its levels and effects.
Actionable advice:
Consult your doctor before using pterostilbene if you have any form of liver disease.
Target id:
/class/immunosuppressants
Target name:
Immunosuppressant Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene has been shown to modulate immune system activity, which could potentially interfere with the intended effects of immunosuppressant medications.
Actionable advice:
Consult your specialist before taking pterostilbene if you are on any immunosuppressive therapy.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene may have mild antiplatelet properties, which could theoretically increase the risk of bleeding when combined with anticoagulant or antiplatelet medications.
Actionable advice:
Use with caution and consult a healthcare provider if you are taking blood-thinning medications or have a bleeding disorder.
Target id:
/class/cyp3a4-substrates
Target name:
CYP3A4 Substrates
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene may weakly inhibit the CYP3A4 enzyme, which could slightly increase levels of many common medications, though this effect is likely minor.
Actionable advice:
Be aware of this theoretical interaction, but major dose adjustments are unlikely to be needed for most CYP3A4-metabolized drugs.
Target id:
/class/hepatotoxic-agents
Target name:
Hepatotoxic Agents
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining pterostilbene with other substances known to be hard on the liver (e.g., high-dose acetaminophen, excessive alcohol) could theoretically increase the risk of liver stress.
Actionable advice:
Exercise caution and avoid excessive use of other potentially liver-toxic substances while taking pterostilbene.
Target id:
/class/benzodiazepines
Target name:
Benzodiazepines
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene may have mild anxiety-reducing and sedative effects, which could be additive with CNS depressants like benzodiazepines, potentially increasing drowsiness.
Actionable advice:
Use caution when combining with benzodiazepines or other sedating medications, and be aware of potential increased drowsiness.
Target id:
/intervention/resveratrol
Target name:
Resveratrol
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene is structurally similar to resveratrol with higher bioavailability; they may act on similar cellular pathways (like SIRT1 activation) in a complementary manner.
Actionable advice:
Consider taking with resveratrol, as they are often combined in longevity protocols to target similar pathways.
Target id:
/intervention/nmn_systemic_healthspan
Target name:
NMN (Nicotinamide Mononucleotide)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene activates sirtuins, which require NAD+ to function. Co-administration with an NAD+ precursor like NMN may enhance sirtuin-related benefits.
Actionable advice:
Consider taking alongside an NAD+ precursor like NMN or NR to support sirtuin activity.
Target id:
/intervention/nr
Target name:
Nicotinamide Riboside (NR)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Pterostilbene activates sirtuins, which are NAD+-dependent enzymes. Supplementing with NR, an NAD+ precursor, may provide the necessary fuel to support this activity.
Actionable advice:
Consider taking alongside an NAD+ precursor like NR or NMN to support sirtuin activity.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of pterostilbene during pregnancy has not been established, and its use is not recommended due to unknown effects on fetal development.
Actionable advice:
Avoid taking pterostilbene completely if you are pregnant.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if pterostilbene passes into breast milk or what its effects on a nursing infant might be; therefore, its use should be avoided.
Actionable advice:
Avoid taking pterostilbene completely while breastfeeding.