Phosphatidylserine (PS) is a phospholipid that is a critical component of cell membranes, particularly in the brain. It supports membrane fluidity, cell-to-cell communication, and neurotransmitter function. For healthspan, its primary role is in maintaining cognitive function, mitigating age-related cognitive decline, and potentially blunting excessive cortisol response to stress.
Verdict
A safe, targeted supplement for supporting age-related cognitive function.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$15 - $40
Protocol
- Take 100mg two to three times daily, often with food to enhance absorption.
Flags
- May interact with blood thinners (anticoagulants), anticholinergics, and some Alzheimer's medications.
- High doses (>300mg) may cause insomnia or gastrointestinal upset.
- Modern supplements are plant-derived (soy/sunflower) to avoid prion risk from older bovine sources.