Meta Information
ID:phosphatidylserine
Name:Phosphatidylserine
Schema Version:1.5
Alternate Names
- PS
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
15
High Cost:
40
Cost Type:
monthly
Description:
Monthly cost for daily supplementation, not covered by insurance.
Summary
Phosphatidylserine (PS) is a phospholipid that is a critical component of cell membranes, particularly in the brain. It supports membrane fluidity, cell-to-cell communication, and neurotransmitter function. For healthspan, its primary role is in maintaining cognitive function, mitigating age-related cognitive decline, and potentially blunting excessive cortisol response to stress.
Purpose
Supports cognitive function, cell membrane health, and stress response.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
4.5
Justification:
Primarily supports cognitive function and stress response, not systemic aging pathways.
Evidence
Grade:
B
Score:
6.5
Justification:
Human trials show benefits for age-related cognitive decline, but some are older.
Safety
Score:
3
Justification:
Generally recognized as safe (GRAS) with rare, mild side effects at typical doses.
Flags
- May interact with blood thinners (anticoagulants), anticholinergics, and some Alzheimer's medications.
- High doses (>300mg) may cause insomnia or gastrointestinal upset.
- Modern supplements are plant-derived (soy/sunflower) to avoid prion risk from older bovine sources.
Verdict
A safe, targeted supplement for supporting age-related cognitive function.
Created
2026-04-27T00:58:09.386785Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Phosphatidylserine (PS) is a phospholipid that is a critical component of cell membranes, particularly in the brain. It supports membrane fluidity, cell-to-cell communication, and neurotransmitter fun...
Typical Protocol
- Take 100mg two to three times daily, often with food to enhance absorption.