Meta Information
ID:phosphatidylserine
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Phosphatidylserine may have mild blood-thinning properties, which could add to the effects of anticoagulant and antiplatelet medications (e.g., warfarin, clopidogrel, aspirin), potentially increasing the risk of bleeding.
Actionable advice:
Consult your doctor before combining with blood-thinning medications; close monitoring may be required.
Target id:
/procedure/surgery
Target name:
Upcoming Surgery
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Due to its potential blood-thinning effects, phosphatidylserine may increase the risk of excessive bleeding during and after surgical procedures.
Actionable advice:
Discontinue use at least 2 weeks prior to any scheduled surgery and inform your surgeon.
Target id:
/condition/bleeding-disorders
Target name:
Bleeding Disorders
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Due to its potential mild blood-thinning effects, phosphatidylserine could exacerbate bleeding in individuals with pre-existing bleeding disorders like hemophilia or von Willebrand disease.
Actionable advice:
Avoid completely if you have a known bleeding disorder.
Target id:
/class/cholinesterase-inhibitors
Target name:
Cholinesterase Inhibitors
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Both phosphatidylserine and cholinesterase inhibitors (used for Alzheimer's disease, e.g., donepezil, galantamine) increase levels of the neurotransmitter acetylcholine. Combining them may lead to an excessive cholinergic effect and increased side effects like nausea, diarrhea, and salivation.
Actionable advice:
Use only under strict medical supervision when combined with cholinesterase inhibitors.
Target id:
/class/anticholinergic-medications
Target name:
Anticholinergic Medications
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Phosphatidylserine may increase acetylcholine levels, which directly opposes the mechanism of anticholinergic drugs (used for allergies, overactive bladder, etc.). This could reduce the effectiveness of the medication.
Actionable advice:
Avoid using with anticholinergic medications as they have opposing pharmacological effects.
Target id:
/class/cholinergic-agonists
Target name:
Cholinergic Agonist Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Phosphatidylserine can increase acetylcholine activity, potentially amplifying the effects and side effects of cholinergic agonist drugs used for conditions like glaucoma or dry mouth (e.g., pilocarpine).
Actionable advice:
Consult a healthcare professional before combining with cholinergic drugs.
Target id:
/dietary/high-fat-meal
Target name:
Fat-Containing Meal
Severity:
moderate
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
As a phospholipid, phosphatidylserine is fat-soluble. Its absorption from the gut is significantly improved when consumed with dietary fats.
Actionable advice:
Take phosphatidylserine with a meal that contains healthy fats like avocado, nuts, seeds, or olive oil.
Target id:
/intervention/omega-3-fatty-acids
Target name:
Omega-3 Fatty Acids (DHA/EPA)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Phosphatidylserine and Omega-3s (especially DHA) are both critical structural components of brain cell membranes. Their combination may synergistically support membrane fluidity, neuronal signaling, and cognitive function.
Actionable advice:
Consider taking with a quality Omega-3 supplement for enhanced brain health benefits.
Target id:
/intervention/alpha-gpc
Target name:
Alpha-GPC
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Phosphatidylserine supports neuronal membranes while Alpha-GPC provides a direct precursor for acetylcholine synthesis. Together, they may offer enhanced support for memory and learning.
Actionable advice:
Can be taken together to potentially enhance cognitive support.
Target id:
/intervention/citicoline
Target name:
Citicoline
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Phosphatidylserine and Citicoline work through complementary pathways to support neuronal health, membrane integrity, and acetylcholine synthesis, potentially offering synergistic cognitive benefits.
Actionable advice:
Can be taken together for comprehensive cognitive and neuronal support.
Target id:
/class/herbal-anticoagulants
Target name:
Herbal Anticoagulants/Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining phosphatidylserine with other supplements that have blood-thinning properties (like ginkgo biloba, garlic, or high-dose fish oil) may have an additive effect, theoretically increasing the risk of bruising or bleeding.
Actionable advice:
Use caution and be aware of potential additive effects when combining with other supplements known to affect blood clotting.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
null
Description:
Phosphatidylserine can help lower high cortisol levels, a stress hormone that should naturally decrease in the evening. This action may aid in relaxation and preparation for sleep.
Actionable advice:
To support a healthy cortisol rhythm for sleep, consider taking a dose in the evening, 1-2 hours before bedtime.
Target id:
/intervention/exercise
Target name:
Strenuous Exercise
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
null
Description:
Taking phosphatidylserine before a workout may help blunt the exercise-induced rise in the stress hormone cortisol, potentially improving recovery and reducing muscle soreness.
Actionable advice:
For athletic recovery benefits, consider taking a dose about one hour before strenuous exercise.