Magnesium L-threonate is a specific form of magnesium chelated with threonic acid, a metabolite of vitamin C. This formulation is designed to enhance magnesium's bioavailability and ability to cross the blood-brain barrier. Its primary relevance to healthspan is its potential to support cognitive function, synaptic density, and sleep quality, all of which decline with age.
Verdict
A promising but pricey option for brain-focused magnesium supplementation.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$20 - $45
Protocol
- Take 1-2 grams daily, often split between afternoon and evening doses.
- Dosing is based on elemental magnesium; 2g of Mag L-threonate yields ~144mg elemental magnesium.
Flags
- May cause drowsiness; often recommended for evening use.
- Individuals with kidney disease should consult a physician before supplementing with magnesium.
- Can interact with certain antibiotics (tetracyclines, quinolones) and bisphosphonates.
- Significantly more expensive than other common forms of magnesium.