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Magnesium L-threonate

Magtein

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Meta Information

ID:magnesium-l-threonate
Name:Magnesium L-threonate
Schema Version:1.5

Alternate Names

  • Magtein

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
20
High Cost:
45
Cost Type:
monthly
Description:
Monthly cost for a standard daily dose from reputable supplement brands.

Summary

Magnesium L-threonate is a specific form of magnesium chelated with threonic acid, a metabolite of vitamin C. This formulation is designed to enhance magnesium's bioavailability and ability to cross the blood-brain barrier. Its primary relevance to healthspan is its potential to support cognitive function, synaptic density, and sleep quality, all of which decline with age.

Purpose

A brain-bioavailable magnesium form for cognitive health and sleep.

Drug Class

magnesium

Drugs In Class

Empty Array

Impact

Score:
4.5
Justification:
Targets cognitive health and sleep, but lacks broad, systemic anti-aging evidence.

Evidence

Grade:
B
Score:
5.5
Justification:
Small human trials exist, but strong mechanistic evidence is primarily from animal models.

Safety

Score:
2.5
Justification:
Generally recognized as safe (GRAS); high doses may cause mild gastrointestinal upset.

Flags

  • May cause drowsiness; often recommended for evening use.
  • Individuals with kidney disease should consult a physician before supplementing with magnesium.
  • Can interact with certain antibiotics (tetracyclines, quinolones) and bisphosphonates.
  • Significantly more expensive than other common forms of magnesium.

Verdict

A promising but pricey option for brain-focused magnesium supplementation.

Created

2026-04-25T22:22:35.730525Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
Magnesium L-threonate is a specific form of magnesium chelated with threonic acid, a metabolite of vitamin C. This formulation is designed to enhance magnesium's bioavailability and ability to cross t...

Typical Protocol

  • Take 1-2 grams daily, often split between afternoon and evening doses.
  • Dosing is based on elemental magnesium; 2g of Mag L-threonate yields ~144mg elemental magnesium.