Meta Information
ID:magnesium-l-threonate
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The kidneys are responsible for excreting excess magnesium; in renal impairment, magnesium can accumulate to toxic levels, causing severe cardiovascular and neurological complications.
Actionable advice:
Avoid magnesium supplements or use only under strict medical supervision if you have moderate to severe kidney disease.
Target id:
/class/chelating-antibiotics
Target name:
Chelating Antibiotics (Tetracyclines, Quinolones)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
4
Description:
Magnesium binds to tetracycline and fluoroquinolone antibiotics in the gut, forming non-absorbable complexes that severely reduce the antibiotic's effectiveness.
Actionable advice:
Take magnesium at least 2 hours before or 4 hours after taking these types of antibiotics.
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Magnesium can bind to bisphosphonate drugs (e.g., for osteoporosis), significantly reducing their absorption and efficacy.
Actionable advice:
Separate magnesium doses from bisphosphonate medications by at least 2 hours.
Target id:
/intervention/levothyroxine_systemic_disease
Target name:
Levothyroxine
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
4
Description:
Magnesium can interfere with the absorption of thyroid hormone medication in the gastrointestinal tract, potentially reducing its effectiveness.
Actionable advice:
Wait at least 4 hours after taking levothyroxine before taking magnesium.
Target id:
/class/chelating-minerals
Target name:
Other Divalent Minerals (Calcium, Zinc, Iron)
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Magnesium competes with other divalent minerals like calcium, zinc, and iron for the same absorption pathways in the small intestine, reducing the absorption of all involved.
Actionable advice:
Separate magnesium from high-dose calcium, zinc, or iron supplements by at least 2 hours.
Target id:
/class/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Long-term use of PPIs can impair active magnesium absorption in the intestine, leading to a deficiency (hypomagnesemia) that may require supplementation.
Actionable advice:
If on long-term PPI therapy, monitor magnesium levels and consider supplementation as advised by your doctor.
Target id:
/class/diuretics
Target name:
Diuretics (Water Pills)
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Many diuretics, particularly loop and thiazide types, increase the excretion of magnesium through the kidneys, potentially leading to deficiency over time.
Actionable advice:
Monitor magnesium status and consider supplementation if taking these diuretics long-term.
Target id:
/class/calcium-channel-blockers
Target name:
Calcium Channel Blockers
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Magnesium has mild calcium channel blocking properties and can enhance the blood pressure-lowering and heart rate-slowing effects of these medications, potentially leading to hypotension.
Actionable advice:
Use with caution and monitor blood pressure if taking calcium channel blockers concurrently.
Target id:
/class/viscous-fibers
Target name:
Viscous Fibers (e.g., Psyllium)
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Gel-forming fibers can trap magnesium in the gut, forming a matrix that prevents its absorption into the bloodstream.
Actionable advice:
Take magnesium at least 2 hours before or after consuming viscous fiber supplements.
Target id:
/intervention/digoxin
Target name:
Digoxin
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Magnesium can reduce the absorption of digoxin, a heart medication; separately, low magnesium levels can increase the risk of digoxin toxicity.
Actionable advice:
Separate magnesium and digoxin doses by at least 2 hours and ensure magnesium levels are adequate.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1.5
Hours after target:
null
Description:
Magnesium L-threonate is unique in its ability to cross the blood-brain barrier, where it can promote relaxation and support neural pathways involved in sleep and memory consolidation.
Actionable advice:
Take 1-2 hours before bedtime to support sleep quality and cognitive function.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking magnesium with food can help reduce the risk of gastrointestinal side effects such as diarrhea or stomach upset, which can occur with higher doses.
Actionable advice:
Take with a small meal or snack to improve gastrointestinal tolerance.
Target id:
/dietary/phytate-rich-foods
Target name:
High-Phytate Meal (Grains, Legumes)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Phytic acid, found in whole grains, legumes, and nuts, can bind to magnesium in the gut, forming an insoluble complex that modestly reduces its absorption.
Actionable advice:
For maximum absorption, take at least 2 hours away from meals very high in unprocessed grains or legumes.
Target id:
/class/benzodiazepines
Target name:
Benzodiazepines
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Due to its effects on the central nervous system via NMDA receptor modulation, magnesium may enhance the sedative effects of benzodiazepines and other CNS depressants.
Actionable advice:
Use with caution and be aware of potential increased drowsiness when combining with sedative medications.
Target id:
/class/potassium-sparing-diuretics
Target name:
Potassium-Sparing Diuretics
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Some potassium-sparing diuretics (e.g., amiloride, triamterene) can also reduce magnesium excretion, slightly increasing the risk of high magnesium levels (hypermagnesemia).
Actionable advice:
Monitor magnesium levels if using concurrently, especially if you have any degree of kidney impairment.
Target id:
/biomarker/rbc-magnesium
Target name:
RBC Magnesium Test
Severity:
minor
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
null
Description:
Supplementing with magnesium will directly increase measured levels of magnesium in red blood cells, which is the intended therapeutic effect and not a true interference.
Actionable advice:
Inform your healthcare provider about your magnesium supplementation when interpreting RBC magnesium test results.