Magnesium is an essential mineral and a cofactor in over 300 enzymatic systems, including those for ATP production, DNA repair, and protein synthesis. Its healthspan relevance is tied to its role in maintaining genomic stability, reducing chronic inflammation, improving insulin sensitivity, and supporting cardiovascular function. Magnesium chloride is a salt form of magnesium known for its high bioavailability and solubility.
Verdict
A safe, foundational supplement for correcting a common, impactful deficiency.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$10 - $30
Protocol
- Take a daily dose equivalent to 200-400mg of elemental magnesium, often split to improve absorption and reduce GI side effects.
Flags
- Can cause diarrhea or stomach upset, especially at higher doses or on an empty stomach.
- Individuals with impaired kidney function should consult a physician before supplementing.
- May reduce the absorption of certain antibiotics (tetracyclines, quinolones) and bisphosphonates.