Meta Information
ID:magnesium-chloride
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/renal-impairment
Target name:
Renal Impairment (Kidney Disease)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Individuals with impaired kidney function cannot effectively clear excess magnesium from the body, leading to a high risk of dangerous accumulation (hypermagnesemia) and toxicity.
Actionable advice:
Avoid magnesium supplements unless specifically directed and monitored by a physician if you have any degree of kidney disease.
Target id:
/class/chelating-antibiotics
Target name:
Chelating Antibiotics (Tetracyclines, Quinolones)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
6
Description:
Magnesium ions bind to tetracycline and fluoroquinolone antibiotics in the gut, forming an insoluble complex that prevents the antibiotic from being absorbed.
Actionable advice:
Take magnesium at least 2 hours before or 6 hours after these types of antibiotics.
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Magnesium ions can bind to bisphosphonate medications (for osteoporosis), significantly reducing their absorption from the gastrointestinal tract and lowering their effectiveness.
Actionable advice:
Separate magnesium doses from bisphosphonate medications by at least 2 hours.
Target id:
/condition/myasthenia-gravis
Target name:
Myasthenia Gravis
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Magnesium can inhibit nerve-muscle communication at the neuromuscular junction, which can worsen muscle weakness in people with myasthenia gravis.
Actionable advice:
Avoid magnesium supplements if you have myasthenia gravis, except under strict medical supervision.
Target id:
/intervention/levothyroxine_systemic_disease
Target name:
Levothyroxine
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
4
Description:
Magnesium can form complexes with levothyroxine in the gut, impairing its absorption and potentially leading to reduced thyroid hormone levels and efficacy.
Actionable advice:
Separate magnesium and levothyroxine doses by at least 4 hours.
Target id:
/class/potassium-sparing-diuretics
Target name:
Potassium-Sparing Diuretics
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
These diuretics reduce the amount of magnesium lost in the urine, increasing the risk of high magnesium levels (hypermagnesemia) when taking supplements.
Actionable advice:
Use caution and monitor magnesium levels when combining with potassium-sparing diuretics.
Target id:
/class/loop-diuretics
Target name:
Loop Diuretics
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Loop diuretics (e.g., furosemide) increase the urinary excretion of magnesium, which can lead to magnesium depletion over time with chronic use.
Actionable advice:
Monitor magnesium levels if taking loop diuretics long-term, as supplementation may be necessary to prevent deficiency.
Target id:
/class/proton-pump-inhibitors
Target name:
Proton Pump Inhibitors (PPIs)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Long-term use of PPIs can impair the absorption of magnesium from the diet and supplements by reducing stomach acid, potentially leading to deficiency.
Actionable advice:
If using PPIs long-term, periodically monitor magnesium levels.
Target id:
/class/calcium-supplements
Target name:
Calcium Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
High doses of calcium and magnesium compete for the same absorption pathways in the gut, which can reduce the absorption of both minerals.
Actionable advice:
Separate high-dose calcium and magnesium supplements by at least 2 hours.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking magnesium chloride with food can significantly improve gastrointestinal tolerance and reduce the risk of its common side effect, diarrhea.
Actionable advice:
Take magnesium chloride with a meal to minimize stomach upset.
Target id:
/intervention/vitamin_d3_systemic_healthspan
Target name:
Vitamin D
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Adequate Vitamin D levels are necessary for the efficient absorption of magnesium from the intestines and its utilization within the body.
Actionable advice:
Ensure adequate Vitamin D status for optimal magnesium absorption and function.
Target id:
/intervention/digoxin
Target name:
Digoxin
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Low magnesium levels (hypomagnesemia) can increase the risk of digoxin toxicity. Conversely, very high magnesium can interfere with its cardiac effects.
Actionable advice:
Maintain normal magnesium levels and consult a doctor before supplementing if taking digoxin.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
null
Description:
Magnesium supports neurotransmitter function, such as GABA, which promotes relaxation and can help improve sleep onset and quality.
Actionable advice:
Take magnesium 30-60 minutes before bedtime to support relaxation and sleep.
Target id:
/intervention/zinc
Target name:
Zinc
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Very high doses of zinc (>142 mg/day) can interfere with magnesium absorption; similarly, high doses of magnesium may slightly reduce zinc absorption.
Actionable advice:
Separate high-dose zinc and magnesium supplements by at least 2 hours.
Target id:
/class/iron-supplements
Target name:
Iron Supplements
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
High doses of magnesium can slightly reduce the absorption of non-heme iron supplements when taken at the same time due to competition for transporters.
Actionable advice:
Separate high-dose iron and magnesium supplements by at least 2 hours.
Target id:
/dietary/phytate-rich-foods
Target name:
Phytate-Rich Foods (Grains, Legumes, Nuts)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Phytic acid, found in plant-based foods like whole grains and legumes, can bind to magnesium in the gut and inhibit its absorption.
Actionable advice:
For maximum absorption, separate magnesium supplements from very high-phytate meals by 2 hours.
Target id:
/class/calcium-channel-blockers
Target name:
Calcium Channel Blockers
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Magnesium has mild calcium channel blocking properties, which can add to the effects of these medications, potentially causing excessive blood pressure lowering or dizziness.
Actionable advice:
Monitor blood pressure when combining magnesium supplements with calcium channel blockers.
Target id:
/intervention/vitamin-b6
Target name:
Vitamin B6
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin B6 acts as a cofactor that helps transport magnesium into cells, potentially enhancing its effectiveness and cellular uptake.
Actionable advice:
Consider taking Vitamin B6 alongside magnesium to potentially improve its cellular uptake.
Target id:
/biomarker/rbc-magnesium
Target name:
RBC Magnesium
Severity:
major
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Supplementation with magnesium chloride is intended to increase cellular magnesium levels, which are best measured by the Red Blood Cell (RBC) magnesium test.
Actionable advice:
Use RBC magnesium testing to monitor status and guide supplementation dosage, aiming for the upper end of the reference range.