LSD is a classical psychedelic that primarily acts as a serotonin 5-HT2A receptor agonist. This action is thought to promote neuroplasticity, increase BDNF expression, and potentially exert anti-inflammatory effects in the brain. Its relevance to healthspan is speculative, focusing on the hypothesis that enhanced cognitive flexibility and improved mental health may contribute to a longer period of high-functioning life.
Verdict
Highly speculative for healthspan with significant legal and psychological risks.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
High
EVIDENCE GRADE
C
MONTHLY COST
$50 - $150
Protocol
- A microdose of 5-20 micrograms is taken every two to three days.
Flags
- Illegal in most jurisdictions, sourcing carries significant legal and safety risks.
- Can precipitate or exacerbate psychosis in predisposed individuals.
- Risk of Hallucinogen Persisting Perception Disorder (HPPD) exists, though rare.
- Contraindicated with lithium; interacts unpredictably with SSRIs and other psychiatric medications.
- Unregulated supply means dosage and purity are highly unreliable.