Meta Information

ID:lsd

Name:LSD

Schema Version:1.5

Title

LSD

Alternate Names

• Lysergic acid diethylamide
• Acid

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

50

High Cost:

150

Cost Type:

monthly

Description:

Illicit market cost for a typical microdosing protocol.

Summary

LSD is a classical psychedelic that primarily acts as a serotonin 5-HT2A receptor agonist. This action is thought to promote neuroplasticity, increase BDNF expression, and potentially exert anti-inflammatory effects in the brain. Its relevance to healthspan is speculative, focusing on the hypothesis that enhanced cognitive flexibility and improved mental health may contribute to a longer period of high-functioning life.

Purpose

Serotonergic psychedelic proposed to enhance neuroplasticity and mental well-being.

Card Summary

A classic serotonergic psychedelic investigated for its potential to enhance neuroplasticity, creativity, and mental well-being through microdosing protocols.

Drug Class

classical_psychedelic

Drugs In Class

Empty Array

Impact

Score:

3.2

Justification:

Indirect benefits via mental health and neuroplasticity; no direct longevity evidence.

Evidence

Grade:

C

Score:

3.5

Justification:

Human trials exist for mental health, but healthspan evidence is anecdotal or preclinical.

Safety

Score:

7.8

Justification:

Illicit status, variable dosage/purity, and significant psychological risks require extreme caution.

Flags

• Illegal in most jurisdictions, sourcing carries significant legal and safety risks.
• Can precipitate or exacerbate psychosis in predisposed individuals.
• Risk of Hallucinogen Persisting Perception Disorder (HPPD) exists, though rare.
• Contraindicated with lithium; interacts unpredictably with SSRIs and other psychiatric medications.
• Unregulated supply means dosage and purity are highly unreliable.

Verdict

Highly speculative for healthspan with significant legal and psychological risks.

Created

2026-04-23T23:42:12.210890Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

multiple

Scope:

• systemic

Indication

Focus:

healthspan

Description:

LSD is a classical psychedelic that primarily acts as a serotonin 5-HT2A receptor agonist. This action is thought to promote neuroplasticity, increase BDNF expression, and potentially exert anti-infla...

Typical Protocol

• A microdose of 5-20 micrograms is taken every two to three days.