Meta Information
ID:lsd
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/serotonergic-agents
Target name:
Serotonergic Medications (SSRIs, SNRIs, TCAs, Triptans)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining LSD with other serotonergic drugs dramatically increases the risk of serotonin syndrome, a potentially life-threatening condition caused by excessive serotonin activity.
Actionable advice:
Avoid this combination completely due to the high risk of serotonin syndrome.
Target id:
/class/maois
Target name:
Monoamine Oxidase Inhibitors (MAOIs)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
MAOIs prevent the breakdown of serotonin, and when combined with LSD, can lead to a hypertensive crisis and a severe, life-threatening form of serotonin syndrome.
Actionable advice:
This combination is absolutely contraindicated; a multi-week washout period from MAOIs is required.
Target id:
/intervention/lithium
Target name:
Lithium
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Case reports suggest a high risk of seizures, severe confusion, and unpredictable psychological reactions when LSD is combined with lithium.
Actionable advice:
Avoid this combination completely due to the risk of seizures and severe adverse effects.
Target id:
/class/stimulants
Target name:
Stimulant Medications
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Both LSD and stimulants increase heart rate and blood pressure, and their combination can lead to excessive cardiovascular strain, anxiety, and paranoia.
Actionable advice:
Do not combine with stimulants due to the risk of cardiovascular stress and psychological distress.
Target id:
/intervention/tramadol
Target name:
Tramadol
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Tramadol has serotonergic properties and lowers the seizure threshold, creating a high risk of both serotonin syndrome and seizures when taken with LSD.
Actionable advice:
Avoid this combination completely due to a high risk of seizures and serotonin syndrome.
Target id:
/condition/schizophrenia-psychosis
Target name:
History of Schizophrenia or Psychosis
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
LSD can trigger or worsen psychosis in individuals with a personal or strong family history of psychotic disorders like schizophrenia.
Actionable advice:
This is an absolute contraindication for individuals with a personal or family history of psychosis.
Target id:
/condition/bipolar-disorder
Target name:
Bipolar Disorder
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
LSD can precipitate manic episodes or worsen mood instability in individuals with bipolar disorder.
Actionable advice:
Avoid completely if you have a diagnosis of bipolar disorder due to the risk of inducing mania.
Target id:
/condition/heart-failure
Target name:
Significant Cardiovascular Disease
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The stimulant effects of LSD increase heart rate and blood pressure, which can be dangerous for individuals with pre-existing heart conditions like heart failure or uncontrolled hypertension.
Actionable advice:
Avoid if you have significant cardiovascular disease due to the strain placed on the heart.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of LSD in pregnancy is unknown, and as an ergot derivative, it carries a theoretical risk of uterine vasoconstriction and harm to the fetus.
Actionable advice:
Avoid completely during pregnancy due to unknown but potentially serious risks.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
LSD is presumed to pass into breast milk, and its effects on a developing infant are unknown and potentially harmful.
Actionable advice:
Avoid completely while breastfeeding to prevent infant exposure.
Target id:
/class/antipsychotics
Target name:
Antipsychotic Medications
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Most antipsychotics are 5-HT2A receptor antagonists, directly blocking the primary target of LSD and thereby blunting or completely negating its psychological effects.
Actionable advice:
Avoid taking with LSD as antipsychotics will block the intended psychedelic effects.
Target id:
/intervention/psilocybin-therapy
Target name:
Other Classic Psychedelics (e.g., Psilocybin)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
168
Hours after target:
168
Description:
A rapid and profound cross-tolerance exists between classic serotonergic psychedelics. Using them within a short timeframe will lead to significantly weakened effects.
Actionable advice:
Separate use of classic psychedelics by at least 7-14 days to allow tolerance to reset.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
12
Hours after target:
null
Description:
LSD is a potent central nervous system stimulant that significantly disrupts sleep architecture and makes it very difficult to fall asleep for the duration of its effects.
Actionable advice:
Take early in the day, as LSD will prevent or impair sleep for approximately 10-12 hours.
Target id:
/class/qt-prolonging-agents
Target name:
QT-Prolonging Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
LSD may have a mild QT-prolonging effect on heart rhythm. Combining it with other drugs that do the same could increase the risk of a serious arrhythmia.
Actionable advice:
Use with caution and avoid combining with other QT-prolonging drugs, especially with a pre-existing heart condition.
Target id:
/class/benzodiazepines
Target name:
Benzodiazepines
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Benzodiazepines act as central nervous system depressants and can reduce the anxiety, emotional intensity, and overall subjective effects of the LSD experience.
Actionable advice:
Avoid taking before or during the experience if seeking full effects, as they will dampen the intensity.
Target id:
/intervention/cannabis
Target name:
Cannabis
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Cannabis can unpredictably and significantly intensify the psychological effects of LSD, which may increase the risk of anxiety, paranoia, and confusion.
Actionable advice:
Avoid this combination, especially if inexperienced, as it can lead to a more challenging and unpredictable experience.
Target id:
/class/cyp3a4-strong-inhibitors
Target name:
Strong CYP3A4 Inhibitors
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
48
Hours after target:
12
Description:
Strong inhibitors of the CYP3A4 enzyme can slow the metabolism of LSD, leading to higher blood levels and a more intense, prolonged, and unpredictable experience.
Actionable advice:
Avoid strong CYP3A4 inhibitors for at least 48 hours before taking LSD.
Target id:
/dietary/grapefruit-pomelo
Target name:
Grapefruit
Severity:
moderate
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
24
Hours after target:
12
Description:
Grapefruit is a moderate inhibitor of the CYP3A4 enzyme, which can slow the metabolism of LSD and result in a stronger and longer-lasting effect than intended.
Actionable advice:
Avoid grapefruit and its juice for at least 24 hours before taking LSD.
Target id:
/class/broad-spectrum-inducers
Target name:
Metabolic Enzyme Inducers (e.g., St. John's Wort)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Substances that induce metabolic enzymes like CYP3A4 can speed up the breakdown of LSD, potentially reducing the intensity and duration of its effects.
Actionable advice:
Be aware that chronic use of enzyme inducers like St. John's Wort may weaken the effects of LSD.
Target id:
/class/ergot-alkaloids
Target name:
Ergot-Derived Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
LSD is an ergot derivative. Combining it with other ergot alkaloids (e.g., for migraines) carries a theoretical risk of additive vasoconstrictive effects (ergotism).
Actionable advice:
Avoid combining with other ergot-derived medications due to a theoretical risk of excessive vasoconstriction.