L-Glutamine is the most abundant amino acid in the body and a primary fuel source for intestinal and immune cells. Its healthspan relevance stems from its role in maintaining gut barrier integrity, which can help reduce systemic inflammation and endotoxemia, key drivers of age-related decline.
Verdict
A safe, targeted supplement for supporting gut barrier function.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$10 - $30
Protocol
- Typical doses for gut health range from 5 to 15 grams daily, often in divided doses.
Flags
- High doses (>20g) may cause mild gastrointestinal distress.
- Individuals with kidney or liver disease should consult a physician before use.
- May interact with anti-seizure medications due to its conversion to glutamate.
- Theoretical concern over fueling cancer cell proliferation, though human evidence from oral supplementation is lacking.