Meta Information

ID:l-glutamine

Name:L-Glutamine

Schema Version:1.5

Alternate Names

• Glutamine

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

10

High Cost:

30

Cost Type:

monthly

Description:

Widely available and inexpensive as a bulk powder supplement.

Summary

L-Glutamine is the most abundant amino acid in the body and a primary fuel source for intestinal and immune cells. Its healthspan relevance stems from its role in maintaining gut barrier integrity, which can help reduce systemic inflammation and endotoxemia, key drivers of age-related decline.

Purpose

Amino acid for gut barrier integrity and immune function.

Card Summary

A conditionally essential amino acid that fuels gut and immune cells, potentially reducing systemic inflammation.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Primarily supports gut integrity; limited direct evidence for extending healthspan in healthy individuals.

Evidence

Grade:

B

Score:

5.5

Justification:

Human trials exist for specific clinical conditions, not for general longevity or healthspan.

Safety

Score:

2.5

Justification:

Generally Recognized As Safe (GRAS) amino acid with a high safety threshold.

Flags

• High doses (>20g) may cause mild gastrointestinal distress.
• Individuals with kidney or liver disease should consult a physician before use.
• May interact with anti-seizure medications due to its conversion to glutamate.
• Theoretical concern over fueling cancer cell proliferation, though human evidence from oral supplementation is lacking.

Verdict

A safe, targeted supplement for supporting gut barrier function.

Created

2026-04-26T18:09:55.049079Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

multiple

Scope:

• systemic

Indication

Focus:

healthspan

Description:

L-Glutamine is the most abundant amino acid in the body and a primary fuel source for intestinal and immune cells. Its healthspan relevance stems from its role in maintaining gut barrier integrity, wh...

Typical Protocol

• Typical doses for gut health range from 5 to 15 grams daily, often in divided doses.