Meta Information
ID:l-glutamine
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/hepatic-impairment
Target name:
Severe Liver Disease / Hepatic Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
In severe liver disease, the body cannot effectively clear ammonia, a byproduct of glutamine metabolism, which can worsen or trigger hepatic encephalopathy.
Actionable advice:
Avoid L-Glutamine completely if you have severe liver disease or cirrhosis.
Target id:
/condition/renal-impairment
Target name:
Severe Kidney Disease / Renal Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Impaired kidney function can lead to difficulty clearing the nitrogenous waste products from glutamine metabolism, potentially worsening the condition.
Actionable advice:
Avoid L-Glutamine completely if you have severe kidney disease (e.g., CKD stage 4-5).
Target id:
/class/chemotherapy-radiation
Target name:
Chemotherapy & Radiation
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Some cancer cells use glutamine as a primary fuel source, and supplementation could theoretically promote tumor growth or interfere with the effectiveness of cancer treatments.
Actionable advice:
Do not take L-Glutamine during active cancer treatment unless specifically directed by your oncologist.
Target id:
/class/anticonvulsants
Target name:
Anticonvulsant Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
L-Glutamine can be converted into the excitatory neurotransmitter glutamate, which may counteract the effects of medications designed to reduce seizure activity.
Actionable advice:
Consult your neurologist before using L-Glutamine if you take seizure medication.
Target id:
/condition/bipolar-disorder
Target name:
Bipolar Disorder
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
As a precursor to the excitatory neurotransmitter glutamate, L-Glutamine could theoretically shift neurochemical balance and potentially trigger manic episodes in susceptible individuals.
Actionable advice:
Use with extreme caution and consult your psychiatrist before taking L-Glutamine if you have bipolar disorder.
Target id:
/dietary/hot-foods-beverages
Target name:
Hot Liquids (e.g., coffee, tea)
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
L-Glutamine is heat-sensitive and can degrade when mixed with hot liquids, reducing its potency and effectiveness.
Actionable advice:
Mix L-Glutamine powder with cool or room-temperature liquids only.
Target id:
/intervention/lactulose
Target name:
Lactulose
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
L-Glutamine metabolism can produce ammonia, potentially counteracting the ammonia-lowering effects of lactulose, especially in individuals with liver disease.
Actionable advice:
Avoid L-Glutamine if you are taking lactulose for hepatic encephalopathy.
Target id:
/condition/reyes-syndrome
Target name:
Reye's Syndrome
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Reye's syndrome is associated with high ammonia levels, and L-Glutamine metabolism can increase the ammonia load, worsening the condition.
Actionable advice:
L-Glutamine is contraindicated in Reye's Syndrome.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
1
Description:
Food, especially protein, contains other amino acids that can compete with L-Glutamine for absorption, potentially reducing its bioavailability.
Actionable advice:
Take L-Glutamine on an empty stomach, at least 30 minutes before or 1 hour after a meal.
Target id:
/intervention/exercise
Target name:
Intense Exercise
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
1
Description:
Intense exercise depletes glutamine stores; supplementing post-workout helps replenish these levels, which may support muscle recovery and immune function.
Actionable advice:
For recovery benefits, consume L-Glutamine within one hour after finishing your workout.
Target id:
/class/amino-acids
Target name:
Other Single Amino Acid Supplements
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
0.5
Description:
High doses of L-Glutamine may compete with other amino acids for transport and absorption in the gut.
Actionable advice:
For optimal absorption, take L-Glutamine at least 30 minutes away from other single amino acid supplements.
Target id:
/condition/msg-sensitivity
Target name:
Monosodium Glutamate (MSG) Sensitivity
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
L-Glutamine can be converted to glutamate in the body, which may trigger symptoms in individuals who are highly sensitive to MSG.
Actionable advice:
If you are sensitive to MSG, start with a very low dose of L-Glutamine to assess tolerance.