Ipamorelin is a synthetic peptide that selectively stimulates the pituitary gland to release growth hormone (GH) by mimicking the hormone ghrelin. Its relevance to healthspan is based on the hypothesis that restoring youthful GH levels can counteract age-related declines in muscle mass, bone density, and tissue repair. Unlike other secretagogues, it has minimal effect on cortisol or prolactin, making it a more targeted intervention.
Verdict
Experimental peptide for GH restoration with unproven long-term safety and benefits.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
High
EVIDENCE GRADE
C
MONTHLY COST
$100 - $300
Protocol
- Subcutaneous injections of 100-300 mcg are taken once or twice daily, often before bed.
- Protocols frequently involve cycling, such as 5 days on and 2 days off per week.
Flags
- Not FDA-approved for anti-aging or general use.
- Banned by the World Anti-Doping Agency (WADA).
- Long-term elevation of IGF-1 is a theoretical cancer risk.
- Sourcing from unregulated suppliers carries significant quality and purity risks.
- Contraindicated for individuals with active or previous cancers.
- Potential side effects include water retention, numbness, and injection site reactions.