Meta Information
ID:ipamorelin
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/dietary/meal
Target name:
Any Caloric Meal (especially carbohydrates and fats)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
2
Description:
Ingesting carbohydrates or fats raises blood glucose and insulin, which stimulates the release of somatostatin, a hormone that directly blocks the pituitary gland's release of growth hormone.
Actionable advice:
Administer Ipamorelin at least 2 hours after your last meal and wait at least 1 hour before eating again.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
major
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
null
Description:
The body's largest natural pulse of growth hormone occurs during the first few hours of deep sleep. Taking Ipamorelin just before bed amplifies this natural, crucial release.
Actionable advice:
For optimal results, administer your dose within 30 minutes of going to bed.
Target id:
/intervention/cjc-1295
Target name:
CJC-1295 (and other GHRHs)
Severity:
major
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Ipamorelin (a GHRP) and CJC-1295 (a GHRH) act on different receptors in the pituitary to create a powerful synergistic release of growth hormone, far greater than either compound alone.
Actionable advice:
Administer Ipamorelin and CJC-1295 at the exact same time for a combined, amplified effect.
Target id:
/condition/active-cancer
Target name:
Active Cancer
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Growth hormone and its downstream mediator, IGF-1, are potent cellular growth promoters (mitogens). Their elevation could potentially accelerate the growth of existing tumors.
Actionable advice:
Do not use Ipamorelin if you have a current or recent history of cancer; it is absolutely contraindicated.
Target id:
/condition/diabetes-mellitus
Target name:
Diabetes Mellitus
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Growth hormone is a counter-regulatory hormone to insulin, meaning it can raise blood sugar levels and increase insulin resistance, making glucose management more difficult.
Actionable advice:
Avoid using Ipamorelin if you have diabetes, unless under the strict supervision of an endocrinologist.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Ipamorelin can increase blood glucose, directly opposing the action of diabetes medications and complicating glycemic control, which can be dangerous.
Actionable advice:
Do not use Ipamorelin while taking medications for diabetes due to unpredictable effects on blood sugar.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The effects of Ipamorelin on fetal development are unknown and could be harmful. It is not studied in pregnant women.
Actionable advice:
Do not use Ipamorelin if you are pregnant.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is not known if Ipamorelin or its metabolites are excreted in breast milk or what effects they might have on a nursing infant.
Actionable advice:
Do not use Ipamorelin while breastfeeding.
Target id:
/biomarker/igf-1
Target name:
Insulin-like Growth Factor 1 (IGF-1)
Severity:
major
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
IGF-1 is the primary downstream mediator of growth hormone and the best biomarker for assessing the biological effect and safety of Ipamorelin therapy. Chronically elevated levels are associated with health risks.
Actionable advice:
Regularly monitor IGF-1 blood levels to ensure they remain within a safe, optimal range for your age.
Target id:
/class/somatostatin-analogs
Target name:
Somatostatin Analogs (e.g., Octreotide)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Somatostatin is the natural 'off switch' for growth hormone release. Somatostatin analog drugs will directly block the action of Ipamorelin at the pituitary gland.
Actionable advice:
Avoid using Ipamorelin completely if you are taking a somatostatin analog medication.
Target id:
/intervention/resistance-training
Target name:
Resistance Training
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
1
Description:
Intense exercise naturally suppresses somatostatin, creating an ideal window for an enhanced growth hormone pulse. Administering Ipamorelin post-workout can capitalize on this state.
Actionable advice:
Administer your dose within 1 hour after completing a resistance training session for enhanced effect.
Target id:
/class/corticosteroids
Target name:
Corticosteroids
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Corticosteroids can increase blood sugar and somatostatin levels, which may blunt the effectiveness of Ipamorelin's growth hormone pulse.
Actionable advice:
Be aware that the effectiveness of Ipamorelin may be reduced while taking corticosteroid medications.
Target id:
/condition/carpal-tunnel-syndrome
Target name:
Carpal Tunnel Syndrome
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Increased growth hormone and IGF-1 levels can cause fluid retention in tissues, which can compress the median nerve in the wrist and worsen symptoms of carpal tunnel syndrome.
Actionable advice:
Use with caution or avoid if you have a history of carpal tunnel syndrome, and discontinue if symptoms appear.
Target id:
/biomarker/fasting-glucose
Target name:
Fasting Glucose
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Because growth hormone can induce a state of transient insulin resistance, it is important to monitor its long-term impact on your baseline blood sugar levels.
Actionable advice:
Periodically monitor fasting glucose to ensure healthy glucose metabolism is maintained during therapy.
Target id:
/class/anticholinergic-medications
Target name:
Anticholinergic Medications
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
The neurotransmitter acetylcholine plays a role in stimulating growth hormone release, partly by inhibiting somatostatin. Anticholinergic drugs could theoretically blunt this effect.
Actionable advice:
Be aware that concurrent use of strong anticholinergic drugs may slightly reduce Ipamorelin's effectiveness.
Target id:
/class/choline-precursors
Target name:
Choline Precursors (e.g., Alpha-GPC)
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Increasing acetylcholine levels via choline precursors may inhibit somatostatin, potentially enhancing the growth hormone pulse stimulated by Ipamorelin.
Actionable advice:
Consider taking a choline source like Alpha-GPC at the same time as Ipamorelin for a potential minor boost.