Meta Information

ID:ipamorelin

Name:Ipamorelin

Schema Version:1.5

Title

Ipamorelin

Alternate Names

• NNC 26-0161

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

100

High Cost:

300

Cost Type:

monthly

Description:

Sourced from compounding pharmacies or research chemical suppliers.

Summary

Ipamorelin is a synthetic peptide that selectively stimulates the pituitary gland to release growth hormone (GH) by mimicking the hormone ghrelin. Its relevance to healthspan is based on the hypothesis that restoring youthful GH levels can counteract age-related declines in muscle mass, bone density, and tissue repair. Unlike other secretagogues, it has minimal effect on cortisol or prolactin, making it a more targeted intervention.

Purpose

A selective peptide that stimulates natural growth hormone release.

Card Summary

A selective growth hormone secretagogue peptide that stimulates the pituitary gland to release growth hormone, aiming to restore youthful levels for tissue repair and body composition.

Drug Class

growth-hormone-secretagogues

Drugs In Class

Empty Array

Impact

Score:

4.2

Justification:

Targets age-related GH decline, improving body composition and recovery, but lacks lifespan data.

Evidence

Grade:

C

Score:

3.5

Justification:

Limited human trials, primarily focused on short-term or non-longevity endpoints.

Safety

Score:

7.5

Justification:

Unregulated, potential for long-term IGF-1 elevation risks, requires medical supervision.

Flags

• Not FDA-approved for anti-aging or general use.
• Banned by the World Anti-Doping Agency (WADA).
• Long-term elevation of IGF-1 is a theoretical cancer risk.
• Sourcing from unregulated suppliers carries significant quality and purity risks.
• Contraindicated for individuals with active or previous cancers.
• Potential side effects include water retention, numbness, and injection site reactions.

Verdict

Experimental peptide for GH restoration with unproven long-term safety and benefits.

Created

2026-04-23T23:38:57.340108Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

subcutaneous_injection

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Ipamorelin is a synthetic peptide that selectively stimulates the pituitary gland to release growth hormone (GH) by mimicking the hormone ghrelin. Its relevance to healthspan is based on the hypothesi...

Typical Protocol

• Subcutaneous injections of 100-300 mcg are taken once or twice daily, often before bed.
• Protocols frequently involve cycling, such as 5 days on and 2 days off per week.