Green-Lipped Mussel (GLM) extract is a source of unique omega-3 fatty acids, including eicosatetraenoic acid (ETA), which potently inhibit inflammatory pathways like COX and 5-LOX. Its primary relevance to healthspan is the management of chronic, low-grade inflammation ('inflammaging'), particularly within joints. By reducing pain and improving joint function, GLM supports mobility and physical activity, which are critical components of a long healthspan.
Verdict
A well-evidenced option for managing joint inflammation and supporting mobility.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
A
MONTHLY COST
$20 - $50
Protocol
- Daily intake of 500-1500 mg of a stabilized lipid extract is common.
Flags
- Contraindicated for individuals with shellfish allergies.
- May have mild anti-platelet effects; use caution with anticoagulant medications.
- Lipid content and quality can vary significantly between brands; seek stabilized extracts.