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Green-Lipped Mussel Extract

GLM, Perna canaliculus extract, Lyprinol

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Meta Information

ID:green-lipped-mussel
Name:Green-Lipped Mussel Extract
Schema Version:1.5

Alternate Names

  • GLM
  • Perna canaliculus extract
  • Lyprinol

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
20
High Cost:
50
Cost Type:
monthly
Description:
Monthly cost for daily supplementation, not covered by insurance.

Summary

Green-Lipped Mussel (GLM) extract is a source of unique omega-3 fatty acids, including eicosatetraenoic acid (ETA), which potently inhibit inflammatory pathways like COX and 5-LOX. Its primary relevance to healthspan is the management of chronic, low-grade inflammation ('inflammaging'), particularly within joints. By reducing pain and improving joint function, GLM supports mobility and physical activity, which are critical components of a long healthspan.

Purpose

A marine lipid extract for reducing joint inflammation and pain.

Card Summary

A marine-derived supplement containing unique omega-3s that targets joint inflammation, potentially mitigating age-related mobility decline.

Drug Class

Drugs In Class

Empty Array

Impact

Score:
4.5
Justification:
Targeted benefit for joint inflammation and mobility, a key quality of life factor.

Evidence

Grade:
A
Score:
8.5
Justification:
Multiple human RCTs and meta-analyses confirm efficacy for osteoarthritis symptoms.

Safety

Score:
2.5
Justification:
Generally well-tolerated with main risk being shellfish allergy and mild GI upset.

Flags

  • Contraindicated for individuals with shellfish allergies.
  • May have mild anti-platelet effects; use caution with anticoagulant medications.
  • Lipid content and quality can vary significantly between brands; seek stabilized extracts.

Verdict

A well-evidenced option for managing joint inflammation and supporting mobility.

Created

2026-04-26T18:17:48.247550Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
Green-Lipped Mussel (GLM) extract is a source of unique omega-3 fatty acids, including eicosatetraenoic acid (ETA), which potently inhibit inflammatory pathways like COX and 5-LOX. Its primary relevan...

Typical Protocol

  • Daily intake of 500-1500 mg of a stabilized lipid extract is common.