GlyNAC

GlyNAC is a combination of the amino acid Glycine and the precursor N-Acetylcysteine (NAC). This synergistic therapy aims to correct age-associated glutathione (GSH) deficiency, as both components are necessary for GSH synthesis. Restoring levels of GSH, the body's master antioxidant, has been shown in small human trials to reduce oxidative stress, improve mitochondrial function, and reverse multiple other hallmarks of aging.

Verdict

A promising, low-risk strategy to boost glutathione and combat cellular aging.

Protocol

• A common research protocol involves daily doses of approximately 100 mg/kg for both Glycine and NAC.
• This total daily amount is often split into two doses to improve gastrointestinal tolerance.

Flags

• NAC can cause nausea, vomiting, or diarrhea, especially at higher doses.
• Individuals with asthma should use NAC with caution as it can rarely cause bronchospasm.
• Consult a physician if you have a history of cystine kidney stones.
• NAC may interact with nitroglycerin and some blood pressure medications.