Meta Information
ID:glynac
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/nitrates
Target name:
Nitrate Medications
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The N-Acetylcysteine (NAC) component of GlyNAC can significantly amplify the blood pressure-lowering effects of nitrate medications (e.g., nitroglycerin), potentially leading to severe headaches, dizziness, and dangerous drops in blood pressure.
Actionable advice:
Avoid using GlyNAC completely if you are taking any prescribed nitrate medications.
Target id:
/class/chemotherapy-radiation
Target name:
Cytotoxic Cancer Therapies (Chemotherapy & Radiation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
As a potent antioxidant precursor, GlyNAC could theoretically interfere with the effectiveness of chemotherapy or radiation, which often rely on generating oxidative stress to destroy cancer cells.
Actionable advice:
Do not take GlyNAC during active cancer treatment without explicit approval from your oncologist.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The NAC component has mild antiplatelet properties that may increase the risk of bleeding when combined with blood-thinning medications like warfarin, aspirin, clopidogrel, or DOACs.
Actionable advice:
Consult your doctor before using GlyNAC if you take any blood-thinning medication.
Target id:
/dietary/high-protein-meal
Target name:
High-Protein Meal
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
2
Description:
As Glycine and NAC are amino acids, taking them with a large protein meal can lead to competition for absorption in the gut, potentially reducing their bioavailability and effectiveness.
Actionable advice:
Take GlyNAC on an empty stomach, at least 1 hour before or 2 hours after a protein-rich meal.
Target id:
/class/antipsychotics
Target name:
Antipsychotic Medications
Severity:
moderate
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
The Glycine component may interfere with the mechanism of certain antipsychotic drugs, particularly clozapine, potentially reducing their effectiveness.
Actionable advice:
Consult your psychiatrist before using GlyNAC if you are taking antipsychotic medication, especially clozapine.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The NAC component may have a mild vasodilatory effect, which can add to the effects of prescribed blood pressure-lowering drugs, potentially causing dizziness or excessive hypotension.
Actionable advice:
Monitor your blood pressure closely when starting GlyNAC if you are on blood pressure medication.
Target id:
/condition/asthma-copd
Target name:
Asthma and COPD
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
In some individuals with reactive airway diseases, oral NAC can rarely trigger bronchospasm (constriction of airways), potentially worsening symptoms of asthma.
Actionable advice:
Use with caution and consult your doctor before taking GlyNAC if you have a history of asthma.
Target id:
/biomarker/urine-ketone-test
Target name:
Urine Ketone Test
Severity:
moderate
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
null
Description:
The NAC component can react with the reagents in urine ketone test strips (e.g., nitroprusside), causing a false-positive or falsely elevated reading for ketones.
Actionable advice:
Be aware that GlyNAC can cause inaccurate urine ketone test results; use blood ketone testing for accuracy if needed.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1.5
Hours after target:
0.5
Description:
The Glycine component is known to improve subjective sleep quality and reduce sleep latency, partly by lowering core body temperature, which signals the body to sleep.
Actionable advice:
Consider taking a dose of GlyNAC about 1 hour before bedtime to potentially enhance sleep quality.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
0.5
Hours after target:
1.5
Description:
For optimal absorption and to avoid any potential competition with other amino acids from food, GlyNAC is best taken on an empty stomach.
Actionable advice:
Take GlyNAC at least 30 minutes before or 90 minutes after a meal for best results.
Target id:
/condition/histamine-intolerance
Target name:
Histamine Intolerance
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
NAC may inhibit the diamine oxidase (DAO) enzyme, which is responsible for breaking down histamine in the gut, potentially worsening symptoms in sensitive individuals.
Actionable advice:
Use with caution or avoid if you have known histamine intolerance and experience worsening symptoms.
Target id:
/intervention/activated-charcoal
Target name:
Activated Charcoal
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Activated charcoal is a potent adsorbent that will bind to NAC in the gut, preventing its absorption and rendering it completely ineffective.
Actionable advice:
Separate GlyNAC from activated charcoal by at least 2 hours.