Meta Information
ID:glynac
Name:GlyNAC
Schema Version:1.5
Alternate Names
- Glycine + N-Acetylcysteine
- Glycine and NAC
Active Compound
Glycine and N-Acetylcysteine
Intervention Type
synergistic_therapy
Delivery
Route:
oral
Scope:
- systemic
Regulatory Status
- us:dietary_supplement
- eu:food_supplement
Indication
Focus:
healthspan
Description:
To correct age-related glutathione deficiency, reduce oxidative stress, and improve mitochondrial function associated with aging.
Typical Protocol
- A common research protocol involves daily doses of approximately 100 mg/kg for both Glycine and NAC.
- This total daily amount is often split into two doses to improve gastrointestinal tolerance.
Expected Cost Mean
Low Cost:
30
High Cost:
70
Cost Type:
monthly
Description:
Cost for bulk powders or capsules of both supplements; not covered by insurance.
Summary
GlyNAC is a combination of the amino acid Glycine and the precursor N-Acetylcysteine (NAC). This synergistic therapy aims to correct age-associated glutathione (GSH) deficiency, as both components are necessary for GSH synthesis. Restoring levels of GSH, the body's master antioxidant, has been shown in small human trials to reduce oxidative stress, improve mitochondrial function, and reverse multiple other hallmarks of aging.
Purpose
Restores master antioxidant glutathione to combat age-related cellular damage.
Card Summary
A combination of Glycine and NAC that aims to reverse age-related glutathione deficiency, reducing oxidative stress and improving mitochondrial health.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
5.5
Justification:
Promising human data shows reversal of multiple aging hallmarks, but trials are small.
Evidence
Grade:
B
Score:
6.5
Justification:
Positive results from small human RCTs, though replication by independent groups is needed.
Safety
Score:
3
Justification:
Both components are generally recognized as safe; NAC may cause minor GI upset.
Flags
- NAC can cause nausea, vomiting, or diarrhea, especially at higher doses.
- Individuals with asthma should use NAC with caution as it can rarely cause bronchospasm.
- Consult a physician if you have a history of cystine kidney stones.
- NAC may interact with nitroglycerin and some blood pressure medications.
Verdict
A promising, low-risk strategy to boost glutathione and combat cellular aging.
Created
2026-05-05T23:38:59.571811Z
Ai Model
Gemini 2.5 Pro (High)