Glycine is a non-essential amino acid that may become conditionally essential with age as endogenous production declines. It is a primary component of the master antioxidant glutathione and structural protein collagen, and also functions as an inhibitory neurotransmitter. Its healthspan relevance stems from its role in supporting metabolic health, reducing inflammation, improving sleep quality, and potentially mimicking some anti-aging effects of methionine restriction.
Verdict
A safe, cheap supplement for sleep, collagen, and antioxidant support.
HEALTHSPAN IMPACT
Moderate
RISK LEVEL
Low
EVIDENCE GRADE
B
MONTHLY COST
$3 - $10
Protocol
- Take 3-10 grams daily, often before bed to improve sleep quality.
Flags
- May decrease the effectiveness of the antipsychotic drug clozapine (Clozaril).