Meta Information
ID:glycine
Name:Glycine
Schema Version:1.5
Title
Glycine
Alternate Names
- 2-Aminoacetic acid
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
3
High Cost:
10
Cost Type:
monthly
Description:
Bulk powder is extremely cost-effective for daily supplementation.
Summary
Glycine is a non-essential amino acid that may become conditionally essential with age as endogenous production declines. It is a primary component of the master antioxidant glutathione and structural protein collagen, and also functions as an inhibitory neurotransmitter. Its healthspan relevance stems from its role in supporting metabolic health, reducing inflammation, improving sleep quality, and potentially mimicking some anti-aging effects of methionine restriction.
Purpose
Amino acid for glutathione synthesis, collagen, and sleep.
Card Summary
A conditionally essential amino acid that supports glutathione production, collagen integrity, and sleep quality, potentially mimicking methionine restriction.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
5.5
Justification:
Supports foundational processes like glutathione synthesis and sleep, but lacks human lifespan data.
Evidence
Grade:
B
Score:
6.5
Justification:
Human RCTs show improved metabolic markers and sleep; animal data shows lifespan extension.
Safety
Score:
2.5
Justification:
GRAS amino acid with a very high safety threshold; mild GI upset possible.
Flags
- May decrease the effectiveness of the antipsychotic drug clozapine (Clozaril).
Verdict
A safe, cheap supplement for sleep, collagen, and antioxidant support.
Created
2026-04-23T23:36:35.410132Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
multiple
Scope:
- systemic
Indication
Focus:
disease_treatment
Description:
Glycine is a non-essential amino acid that may become conditionally essential with age as endogenous production declines. It is a primary component of the master antioxidant glutathione and structural...
Typical Protocol
- Take 3-10 grams daily, often before bed to improve sleep quality.