Meta Information
ID:glycine
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/intervention/clozapine
Target name:
Clozapine
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Glycine may interfere with the mechanism of action of clozapine, an atypical antipsychotic, potentially reducing its therapeutic effectiveness in treating schizophrenia.
Actionable advice:
Do not take glycine if you are prescribed clozapine, unless specifically approved by your psychiatrist.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
null
Description:
Glycine acts as an inhibitory neurotransmitter in the brain and helps lower core body temperature, both of which facilitate sleep onset and can improve sleep quality.
Actionable advice:
Take your glycine dose approximately 30-60 minutes before your intended bedtime for optimal sleep benefits.
Target id:
/intervention/nac
Target name:
N-Acetylcysteine (NAC)
Severity:
moderate
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Glycine and cysteine (from NAC) are the two primary rate-limiting amino acids for the synthesis of glutathione, the body's master antioxidant. Co-supplementation (as GlyNAC) effectively restores glutathione levels.
Actionable advice:
Take glycine and NAC at the same time to maximize support for glutathione production.
Target id:
/class/benzodiazepines
Target name:
Benzodiazepines and other Sedatives
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Glycine has a calming, inhibitory effect on the central nervous system, which can be additive with the effects of sedative medications, potentially causing excessive drowsiness or dizziness.
Actionable advice:
Use with caution if taking sedative medications, and do not drive or operate heavy machinery until you know how the combination affects you.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
2
Description:
When taken with food, particularly protein, glycine must compete with other amino acids for absorption, which can slow its uptake and blunt the acute peak needed for sleep-promoting effects.
Actionable advice:
For best sleep-related results, take glycine on an empty stomach, at least 2 hours after your last meal.
Target id:
/intervention/collagen-peptides
Target name:
Collagen Peptides
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Collagen is naturally rich in glycine. Supplementing with additional glycine alongside collagen provides an abundance of the key building blocks required for the body's synthesis of new collagen.
Actionable advice:
Taking glycine and collagen together is safe and may provide enhanced support for skin, joint, and connective tissue health.
Target id:
/dietary/high-carbohydrate-meal
Target name:
High-Carbohydrate Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Glycine may improve glucose disposal and insulin sensitivity, potentially helping to moderate the rise in blood sugar after a carbohydrate-containing meal.
Actionable advice:
Consider taking glycine with or just before a meal high in carbohydrates to potentially blunt the post-meal glucose spike.
Target id:
/dietary/high-methionine-meal
Target name:
High-Methionine Meal (e.g., Red Meat)
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Glycine supplementation can help balance the high methionine intake common in diets rich in muscle meats, which is theorized to support longevity by managing homocysteine pathways.
Actionable advice:
Taking glycine with a high-protein meal, such as red meat, may help balance the overall amino acid profile.