Meta Information

ID:fisetin

Name:Fisetin

Schema Version:1.5

Title

Fisetin

Alternate Names

• Smoketree extract
• 3,3',4',7-tetrahydroxyflavone

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

30

High Cost:

70

Cost Type:

monthly

Description:

Cost for a typical monthly supply, varying by brand and dosing protocol.

Summary

Fisetin is a flavonoid polyphenol found in many plants, such as strawberries and apples, with potent senolytic properties. It selectively induces apoptosis (programmed cell death) in senescent cells, which are dysfunctional 'zombie' cells that accumulate with age. By clearing these cells, fisetin may reduce the chronic, low-grade inflammation they secrete (SASP), potentially improving tissue function and mitigating age-related decline.

Purpose

A plant-derived flavonoid used to clear senescent (aging) cells.

Card Summary

A plant-derived flavonoid with potent senolytic properties, meaning it helps clear dysfunctional, inflammatory 'zombie' cells that accumulate with age.

Drug Class

Drugs In Class

Empty Array

Impact

Score:

4.5

Justification:

Potent senolytic in animal models, but human healthspan data is still very limited.

Evidence

Grade:

B

Score:

4

Justification:

Strong animal data and a few small human trials, but large-scale RCTs are needed.

Safety

Score:

3.8

Justification:

Generally well-tolerated, but long-term safety of high-dose intermittent protocols is not established.

Flags

• Very poor oral bioavailability; should be taken with fats or in a liposomal formulation.
• May interact with blood-thinning medications like warfarin due to anti-platelet effects.
• High-dose senolytic protocols lack long-term human safety data.
• Supplement quality and purity can vary significantly between manufacturers.

Verdict

A promising senolytic, but human evidence for longevity is still emerging.

Created

2026-04-23T23:32:50.192019Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Fisetin is a flavonoid polyphenol found in many plants, such as strawberries and apples, with potent senolytic properties. It selectively induces apoptosis (programmed cell death) in senescent cells, ...

Typical Protocol

• Intermittent high-dose senolytic therapy: ~20mg/kg daily for 2-3 consecutive days, repeated monthly or quarterly.
• Chronic low-dose support: 100-500mg taken daily with a source of fat to improve absorption.