Meta Information
ID:fisetin
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/dietary/high-fat-meal
Target name:
Fat-Containing Meal
Severity:
major
Interaction type:
requirement
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Fisetin is a lipophilic (fat-soluble) polyphenol with very poor water solubility, leading to low oral bioavailability. Co-administration with fats or oils significantly enhances its absorption from the gastrointestinal tract.
Actionable advice:
Always take fisetin during or immediately after a meal containing healthy fats like olive oil, avocado, or nuts to ensure absorption.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Fisetin exhibits antiplatelet activity and inhibits CYP2C9, the primary enzyme metabolizing warfarin. This combination can significantly increase the risk of serious bleeding events.
Actionable advice:
Avoid taking fisetin with any anticoagulant (e.g., warfarin, apixaban) or antiplatelet (e.g., aspirin, clopidogrel) medication unless approved and closely monitored by a physician.
Target id:
/class/cyp3a4-substrates
Target name:
CYP3A4 Substrates
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Fisetin is a moderate inhibitor of the CYP3A4 enzyme, which is responsible for metabolizing approximately 50% of clinical drugs. This can increase the plasma concentration and risk of side effects from medications like certain statins, calcium channel blockers, and benzodiazepines.
Actionable advice:
Consult a pharmacist or physician to review your medication list for potential CYP3A4 interactions before starting fisetin.
Target id:
/class/immunosuppressants
Target name:
Calcineurin Inhibitors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Fisetin's inhibition of CYP3A4 can dangerously increase levels of immunosuppressants like tacrolimus and cyclosporine, which have a narrow therapeutic window, leading to a high risk of toxicity.
Actionable advice:
Do not take fisetin if you are on calcineurin inhibitor immunosuppressants following an organ transplant.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Fisetin may lower blood glucose levels through various mechanisms. When combined with insulin or oral hypoglycemic agents, this can lead to an additive effect and increase the risk of hypoglycemia (dangerously low blood sugar).
Actionable advice:
If you have diabetes, monitor your blood glucose levels closely when starting fisetin and consult your doctor, as medication adjustments may be necessary.
Target id:
/procedure/surgery
Target name:
Surgery
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
72
Description:
Due to its antiplatelet effects, fisetin can impair blood clotting and increase the risk of excessive bleeding during and after surgical procedures.
Actionable advice:
Discontinue fisetin at least 2 weeks prior to any scheduled surgery and do not resume until cleared by your surgeon.
Target id:
/class/chemotherapy-radiation
Target name:
Cytotoxic Cancer Therapies (Chemotherapy & Radiation)
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
As a potent antioxidant, fisetin could theoretically interfere with the pro-oxidant mechanisms of action of many chemotherapeutic agents and radiation therapy, potentially reducing their efficacy.
Actionable advice:
Avoid fisetin and other potent antioxidant supplements during active cancer treatment unless specifically directed by your oncologist.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is no safety data on the use of fisetin supplements during pregnancy. Due to unknown effects on fetal development, it is contraindicated.
Actionable advice:
Do not take fisetin supplements if you are pregnant or trying to conceive.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is not known whether fisetin or its metabolites are excreted into breast milk or what their effects might be on a nursing infant. Therefore, its use should be avoided.
Actionable advice:
Do not take fisetin supplements while breastfeeding.
Target id:
/class/antihypertensives
Target name:
Antihypertensive Medications
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Fisetin may exert mild vasodilatory and blood pressure-lowering effects. This could be additive with prescribed antihypertensive drugs, potentially increasing the risk of hypotension (dizziness, lightheadedness).
Actionable advice:
Monitor your blood pressure when initiating fisetin if you are also taking medication to lower blood pressure.
Target id:
/intervention/quercetin
Target name:
Quercetin
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Fisetin and quercetin are structurally similar flavonoids with overlapping biological activities, including senolytic and anti-inflammatory effects. Taking them together may result in additive or synergistic benefits.
Actionable advice:
Consider that taking fisetin and quercetin together may enhance effects but also amplify shared side effects or drug interactions.