Enclomiphene is a selective estrogen receptor modulator (SERM) that blocks estrogen receptors at the pituitary gland. This action increases the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), signaling the testes to produce more testosterone. For healthspan, it offers a way to restore youthful testosterone levels without the testicular shutdown and fertility issues associated with direct testosterone replacement therapy (TRT).
Verdict
A viable TRT alternative for boosting endogenous testosterone, requiring medical guidance.
HEALTHSPAN IMPACT
High Value
RISK LEVEL
High
EVIDENCE GRADE
B
MONTHLY COST
$50 - $150
Protocol
- Daily or every-other-day oral doses of 6.25mg to 25mg are common.
Flags
- Requires a prescription and regular bloodwork monitoring (testosterone, estradiol, LH, FSH).
- Not FDA-approved for male hypogonadism; often sourced from compounding pharmacies.
- Long-term effects on all-cause mortality or specific longevity outcomes are unknown.
- Potential for side effects including headache, nausea, and rare visual disturbances.
- May elevate estradiol levels, which might require management in some individuals.