Meta Information
ID:enclomiphene
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Enclomiphene is a selective estrogen receptor modulator that can interfere with fetal development and is strictly contraindicated during pregnancy.
Actionable advice:
Do not use if you are pregnant or planning to become pregnant.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
It is not known if enclomiphene passes into breast milk, but due to its hormonal effects, it is contraindicated during lactation.
Actionable advice:
Do not use while breastfeeding.
Target id:
/condition/history-thromboembolism
Target name:
History of Blood Clots (DVT/PE)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Drugs in the SERM class have been associated with an increased risk of blood clots (thromboembolic events). Use is contraindicated in individuals with a history of such events.
Actionable advice:
Avoid completely if you have a personal history of deep vein thrombosis or pulmonary embolism.
Target id:
/condition/hepatic-impairment
Target name:
Severe Liver Disease
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Enclomiphene is metabolized by the liver, and its use in individuals with severe liver impairment can lead to drug accumulation and potential toxicity.
Actionable advice:
Avoid completely if you have severe liver disease.
Target id:
/condition/hormone-sensitive-cancer
Target name:
Estrogen-Dependent Tumors
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
As a modulator of estrogen receptors, enclomiphene should not be used in individuals with a history of estrogen-dependent cancers.
Actionable advice:
Avoid completely if you have a history of hormone-sensitive cancers.
Target id:
/class/selective-estrogen-receptor-modulators
Target name:
Other SERMs (e.g., Tamoxifen, Raloxifene)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Combining multiple SERMs leads to unpredictable effects on estrogen receptors and offers no additional benefit, while potentially increasing risks.
Actionable advice:
Do not combine with other selective estrogen receptor modulators.
Target id:
/class/aromatase-inhibitors
Target name:
Aromatase Inhibitors (e.g., Anastrozole)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Description:
Combining enclomiphene (which increases testosterone) with an aromatase inhibitor (which blocks estrogen conversion) can lead to excessively low estrogen levels, causing significant side effects.
Actionable advice:
Avoid co-administration unless under strict medical supervision for a specific purpose.
Target id:
/intervention/testosterone_systemic_healthspan
Target name:
Exogenous Testosterone Therapy
Severity:
major
Interaction type:
diminishing
Nature:
absolute
Description:
Enclomiphene works by stimulating your body's own testosterone production; taking external testosterone suppresses this natural process, making enclomiphene ineffective.
Actionable advice:
Do not use enclomiphene while on testosterone replacement therapy.
Target id:
/biomarker/comprehensive-sex-hormone-panel
Target name:
Hormone Panel (T, E2, LH, FSH, SHBG)
Severity:
major
Interaction type:
requirement
Nature:
absolute
Description:
Regular monitoring of sex hormones is essential to confirm the drug is working as intended and to ensure levels remain within a safe and optimal range.
Actionable advice:
Obtain a baseline hormone panel before starting and monitor periodically during treatment.
Target id:
/biomarker/comprehensive-liver-function-panel
Target name:
Liver Function Panel (AST, ALT)
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Description:
As enclomiphene is processed by the liver, monitoring liver enzymes is a necessary precaution to ensure hepatic safety during treatment.
Actionable advice:
Check your liver function before starting and periodically thereafter.
Target id:
/biomarker/lipid-panel
Target name:
Lipid Panel (Cholesterol, Triglycerides)
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Description:
SERMs can influence cholesterol and triglyceride levels, making it important to monitor your lipid profile during therapy.
Actionable advice:
Monitor your lipid panel at baseline and during treatment.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Description:
There is a theoretical increased risk of blood clots with SERMs, which could counteract the effects of blood-thinning medications. This combination requires caution.
Actionable advice:
Use with caution and discuss with your doctor if you take any blood-thinning medication.
Target id:
/circadian/consistent-time
Target name:
Consistent Daily Timing
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Description:
Taking enclomiphene at the same time each day helps maintain stable blood concentrations, leading to more consistent hormonal effects.
Actionable advice:
Take your dose at the same time every day.
Target id:
/biomarker/lh
Target name:
Luteinizing Hormone (LH) Test
Severity:
major
Interaction type:
assay_interference
Nature:
absolute
Description:
Enclomiphene is designed to increase LH levels. Testing while on the drug reflects its therapeutic effect, not your baseline, untreated state.
Actionable advice:
Understand that LH levels will be elevated on this therapy; this is the intended effect.
Target id:
/biomarker/fsh
Target name:
Follicle-Stimulating Hormone (FSH) Test
Severity:
major
Interaction type:
assay_interference
Nature:
absolute
Description:
Enclomiphene is designed to increase FSH levels. Testing while on the drug reflects its therapeutic effect, not your baseline, untreated state.
Actionable advice:
Understand that FSH levels will be elevated on this therapy; this is the intended effect.
Target id:
/biomarker/total-testosterone
Target name:
Total Testosterone Test
Severity:
major
Interaction type:
assay_interference
Nature:
absolute
Description:
Enclomiphene is designed to increase testosterone levels. Testing while on the drug reflects its therapeutic effect, not your baseline, untreated state.
Actionable advice:
Understand that testosterone levels will be elevated on this therapy; this is the intended effect.
Target id:
/biomarker/estradiol
Target name:
Estradiol Test
Severity:
major
Interaction type:
assay_interference
Nature:
absolute
Description:
By increasing testosterone, enclomiphene also indirectly increases estradiol through aromatization. Testing while on the drug reflects this expected metabolic conversion.
Actionable advice:
Understand that estradiol levels will likely be elevated on this therapy; this is an expected effect.
Target id:
/circadian/wake
Target name:
Morning (Upon Waking)
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
null
Hours after target:
1
Description:
Taking enclomiphene in the morning may help align with the body's natural diurnal rhythm of testosterone production, which is highest upon waking.
Actionable advice:
Consider taking your daily dose within an hour of waking up.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Enclomiphene absorption is not significantly affected by food. Taking it with a meal can improve tolerability and reduce the chance of gastrointestinal upset.
Actionable advice:
May be taken with or without food; take with a meal if you experience stomach upset.
Target id:
/dietary/soy-products
Target name:
High-Dose Phytoestrogen Supplements
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Description:
High concentrations of phytoestrogens (e.g., from soy isoflavone or red clover supplements) could theoretically compete with enclomiphene for estrogen receptor binding, potentially reducing its effectiveness.
Actionable advice:
Avoid high-dose phytoestrogen supplements while taking enclomiphene.
Target id:
/dietary/grapefruit-pomelo
Target name:
Grapefruit or Grapefruit Juice
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Description:
While not specifically studied, grapefruit is a potent inhibitor of metabolic enzymes (CYP3A4) that could potentially alter enclomiphene levels, increasing the risk of side effects.
Actionable advice:
As a precaution, it is best to avoid grapefruit and its juice.
Target id:
/biomarker/complete-blood-count
Target name:
Complete Blood Count (CBC)
Severity:
minor
Interaction type:
requirement
Nature:
absolute
Description:
Monitoring red blood cell counts (hematocrit) is prudent, as significant increases in testosterone can sometimes stimulate red blood cell production.
Actionable advice:
Consider checking a CBC, including hematocrit, at baseline and after several months of therapy.