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Enclomiphene

Enclomiphene Citrate, Androxal

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Meta Information

ID:enclomiphene
Name:Enclomiphene
Schema Version:1.5

Title

Enclomiphene

Alternate Names

  • Enclomiphene Citrate
  • Androxal

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:
50
High Cost:
150
Cost Type:
monthly
Description:
Typically sourced from compounding pharmacies with a prescription.

Summary

Enclomiphene is a selective estrogen receptor modulator (SERM) that blocks estrogen receptors at the pituitary gland. This action increases the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), signaling the testes to produce more testosterone. For healthspan, it offers a way to restore youthful testosterone levels without the testicular shutdown and fertility issues associated with direct testosterone replacement therapy (TRT).

Purpose

A SERM used to increase endogenous testosterone production.

Card Summary

A selective estrogen receptor modulator (SERM) that stimulates the body's own testosterone production without causing testicular shutdown.

Drug Class

serms

Drugs In Class

Empty Array

Impact

Score:
6.2
Justification:
Effectively restores youthful testosterone, impacting muscle, mood, and metabolic health.

Evidence

Grade:
B
Score:
6.5
Justification:
Human RCTs confirm testosterone increase, but long-term healthspan data is lacking.

Safety

Score:
6.1
Justification:
Off-label use with limited long-term safety data requires medical supervision.

Flags

  • Requires a prescription and regular bloodwork monitoring (testosterone, estradiol, LH, FSH).
  • Not FDA-approved for male hypogonadism; often sourced from compounding pharmacies.
  • Long-term effects on all-cause mortality or specific longevity outcomes are unknown.
  • Potential for side effects including headache, nausea, and rare visual disturbances.
  • May elevate estradiol levels, which might require management in some individuals.

Verdict

A viable TRT alternative for boosting endogenous testosterone, requiring medical guidance.

Created

2026-04-23T23:27:18.780146Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:
oral
Scope:
  • systemic

Indication

Focus:
healthspan
Description:
Enclomiphene is a selective estrogen receptor modulator (SERM) that blocks estrogen receptors at the pituitary gland. This action increases the release of Luteinizing Hormone (LH) and Follicle-Stimula...

Typical Protocol

  • Daily or every-other-day oral doses of 6.25mg to 25mg are common.