Meta Information
ID:cissus-quadrangularis
Name:Cissus Quadrangularis
Schema Version:1.5
Alternate Names
- Veldt Grape
- Devil's Backbone
- Hadjod
Intervention Type
therapeutic_agent
Expected Cost Mean
Low Cost:
15
High Cost:
30
Cost Type:
monthly
Description:
Widely available as an over-the-counter herbal supplement.
Summary
Cissus Quadrangularis is a medicinal plant traditionally used for bone and joint health. Its active compounds, such as ketosterones, may support bone healing and reduce joint pain, indirectly promoting healthspan by maintaining mobility and physical function. Some limited evidence also suggests potential benefits for metabolic health.
Purpose
Supports bone density, joint health, and metabolic function.
Card Summary
A plant extract primarily used to support bone healing and reduce joint pain.
Drug Class
Drugs In Class
Empty Array
Impact
Score:
3.5
Justification:
Benefits are targeted to musculoskeletal health, with limited evidence for systemic longevity effects.
Evidence
Grade:
B
Score:
5.5
Justification:
Supported by some small human RCTs for specific endpoints like bone/joint health.
Safety
Score:
3
Justification:
Generally well-tolerated with only mild, infrequent side effects reported in human trials.
Flags
- May lower blood sugar; use with caution if taking diabetes medications.
- Safety during pregnancy and breastfeeding has not been established.
Verdict
Consider for specific joint or bone issues; not a core longevity supplement.
Created
2026-04-26T18:16:07.010395Z
Model
Gemini 3.1 Pro (High)
Delivery
Route:
oral
Scope:
- systemic
Indication
Focus:
healthspan
Description:
Cissus Quadrangularis is a medicinal plant traditionally used for bone and joint health. Its active compounds, such as ketosterones, may support bone healing and reduce joint pain, indirectly promotin...
Typical Protocol
- A typical dose is 500-1000 mg daily, often split into two administrations.