Meta Information
ID:cissus-quadrangularis
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Cissus quadrangularis may lower blood glucose levels, potentially enhancing the effects of antidiabetic drugs and increasing the risk of hypoglycemia (dangerously low blood sugar).
Actionable advice:
Consult your doctor before combining and monitor blood glucose levels closely, as medication dosages may need adjustment.
Target id:
/condition/diabetes-mellitus
Target name:
Diabetes Mellitus
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Due to its blood sugar-lowering properties, individuals with diabetes are at an increased risk of hypoglycemia when taking Cissus, especially if they are on medication.
Actionable advice:
If you have diabetes, consult your physician before use and monitor your blood sugar levels carefully.
Target id:
/procedure/surgery
Target name:
Scheduled Surgery
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Cissus may affect blood glucose levels and potentially has mild CNS depressant effects, which could interfere with blood sugar control and anesthesia during and after surgery.
Actionable advice:
Discontinue use at least 2 weeks before any scheduled surgery.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is insufficient reliable safety data on the use of Cissus during pregnancy. Due to a lack of evidence and theoretical risks, it is contraindicated.
Actionable advice:
Avoid completely during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if the active compounds in Cissus pass into breast milk or what effects they might have on a nursing infant. It should be avoided due to a lack of safety data.
Actionable advice:
Avoid completely while breastfeeding.
Target id:
/class/glucose-lowering-supplements
Target name:
Glucose-Lowering Supplements
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Combining Cissus with other supplements known to lower blood sugar (e.g., berberine, alpha-lipoic acid, cinnamon) can have an additive effect, increasing the risk of hypoglycemia.
Actionable advice:
Use caution and monitor for symptoms of low blood sugar when combining with other glucose-lowering supplements.
Target id:
/class/cns-depressants
Target name:
CNS Depressants (e.g., Benzodiazepines, Alcohol)
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Based on animal studies, Cissus may have mild sedative properties, which could theoretically enhance the drowsiness caused by CNS depressant medications or alcohol.
Actionable advice:
Exercise caution when combining with sedative medications or alcohol, particularly before driving.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking Cissus with food may improve gastrointestinal tolerance and reduce the risk of reported side effects such as gas, dry mouth, or headache.
Actionable advice:
Take Cissus Quadrangularis with a meal to minimize potential stomach discomfort.
Target id:
/class/nsaids
Target name:
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Cissus possesses inherent anti-inflammatory and analgesic properties that may work additively with NSAIDs, potentially enhancing overall pain relief.
Actionable advice:
Be aware that this combination may provide additional pain relief, but do not use it to replace medical advice for chronic conditions.