Meta Information
ID:centella-asiatica
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/hepatic-impairment
Target name:
Hepatic Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High doses or prolonged use of Centella asiatica have been associated with hepatotoxicity in rare case reports. Its use is contraindicated in individuals with pre-existing liver disease as it may exacerbate the condition.
Actionable advice:
Avoid completely if you have any form of liver disease.
Target id:
/procedure/surgery
Target name:
Scheduled Surgery
Severity:
major
Interaction type:
adverse
Nature:
temporal
Temporal spacing:
Hours before target:
336
Hours after target:
null
Description:
Centella asiatica may have sedative, blood-sugar-lowering, and potential antiplatelet effects, which can interfere with anesthesia, glucose control, and increase bleeding risk during and after surgery.
Actionable advice:
Discontinue use at least 2 weeks prior to any scheduled surgical procedure.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
There is insufficient safety data regarding the oral use of Centella asiatica during pregnancy. Due to a lack of evidence and traditional use in some cultures as an abortifacient, it should be avoided.
Actionable advice:
Do not take orally during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if the active compounds in Centella asiatica are excreted into breast milk or what effects they might have on a nursing infant. Its use is not recommended.
Actionable advice:
Avoid taking orally while breastfeeding.
Target id:
/class/cns-depressants
Target name:
Sedatives and Hypnotics
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Centella asiatica can cause drowsiness and has mild sedative properties. Combining it with other central nervous system depressants can lead to additive effects, causing excessive sedation, dizziness, and impaired motor function.
Actionable advice:
Use with caution and consult a healthcare provider before combining with any sedating medications or supplements.
Target id:
/class/benzodiazepines
Target name:
Benzodiazepines
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The anxiolytic and sedative effects of Centella asiatica may be amplified when taken with benzodiazepines, increasing the risk of excessive drowsiness, confusion, and impaired coordination.
Actionable advice:
Avoid combining unless under medical supervision; do not drive or operate heavy machinery.
Target id:
/class/antidiabetic-medications
Target name:
Diabetes Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Animal and some preliminary human studies suggest that Centella asiatica may lower blood glucose levels. This can enhance the effects of antidiabetic drugs, increasing the risk of hypoglycemia (dangerously low blood sugar).
Actionable advice:
Monitor blood glucose levels very closely if combining, and consult your doctor about potential dose adjustments.
Target id:
/class/hepatotoxic-agents
Target name:
Hepatotoxic Medications
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Given the rare potential for liver injury with high-dose or long-term Centella asiatica use, combining it with other substances known to be hard on the liver (e.g., high-dose acetaminophen, certain antifungals, excessive alcohol) could increase the cumulative risk.
Actionable advice:
Avoid concurrent use with other potentially liver-toxic drugs or substances without medical guidance.
Target id:
/class/anticoagulants-antiplatelets
Target name:
Anticoagulants and Antiplatelets
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
In-vitro studies suggest that components of Centella asiatica may have a mild inhibitory effect on platelet aggregation. This creates a theoretical risk of increased bleeding when combined with blood-thinning medications.
Actionable advice:
Use with caution and monitor for signs of increased bruising or bleeding if taking blood thinners.
Target id:
/class/diuretics
Target name:
Diuretics (Water Pills)
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Centella asiatica may possess mild diuretic properties. Taking it alongside prescription diuretics could have an additive effect, potentially increasing the risk of dehydration or electrolyte imbalance.
Actionable advice:
Ensure adequate fluid and electrolyte intake if combining, and use with caution.
Target id:
/class/cyp3a4-substrates
Target name:
CYP3A4 Substrates
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Preclinical (in-vitro) data suggests Centella asiatica may weakly inhibit or induce the CYP3A4 enzyme. This could theoretically alter the metabolism of numerous common medications, though the clinical significance in humans is unknown.
Actionable advice:
Be aware of this theoretical interaction if taking multiple medications; consult a pharmacist for guidance.
Target id:
/class/cyp2c9-substrates
Target name:
Drugs Metabolized by CYP2C9
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Some in-vitro research indicates a potential for Centella asiatica to weakly interact with the CYP2C9 enzyme. This could theoretically affect levels of drugs like warfarin or certain NSAIDs, but this has not been confirmed in humans.
Actionable advice:
Use with caution if taking medications metabolized by CYP2C9 and consult a pharmacist.
Target id:
/class/cyp2d6-substrates
Target name:
CYP2D6 Substrates
Severity:
minor
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Preclinical studies suggest Centella asiatica might weakly influence the CYP2D6 enzyme, which could theoretically alter the metabolism of certain antidepressants, beta-blockers, and opioids. Clinical relevance remains uncertain.
Actionable advice:
Be aware of this theoretical interaction if taking medications metabolized by CYP2D6.
Target id:
/circadian/sleep
Target name:
Going to Sleep
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
null
Description:
Due to its potential mild sedative and anxiolytic (anxiety-reducing) properties, taking Centella asiatica in the evening may align with its calming effects and support sleep readiness without causing significant next-day drowsiness.
Actionable advice:
Consider taking your daily dose in the evening, approximately 1-2 hours before your intended bedtime.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
Taking Centella asiatica with food can help minimize the risk of mild gastrointestinal side effects, such as nausea or stomach upset, which can occur in sensitive individuals.
Actionable advice:
Take with a meal or a small snack to improve gastrointestinal tolerability.