Alpha-ketoglutarate (AKG) is a crucial molecule in the Krebs cycle, central to cellular energy production and metabolism. Its levels decline significantly with age, and supplementation may support metabolic function, act as an ammonia scavenger, and potentially influence epigenetic regulation by serving as a cofactor for TET enzymes.
Verdict
Promising in mice, but awaits confirmation from human clinical trials.
HEALTHSPAN IMPACT
Experimental
RISK LEVEL
Low
EVIDENCE GRADE
C
MONTHLY COST
$40 - $80
Protocol
- Take 1000 mg daily, often split into two doses with or without food.
Flags
- Human evidence is based on a single, non-placebo-controlled, retrospective study.
- High doses contribute significant calcium, a consideration for those with kidney issues.
- Supplement quality and purity can vary significantly between manufacturers.