Meta Information
ID:calcium-akg
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/class/chelating-antibiotics
Target name:
Chelating Antibiotics (Tetracyclines, Quinolones)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
4
Description:
The calcium ion binds to tetracycline and quinolone antibiotics in the gut, forming an insoluble complex that prevents the antibiotic from being absorbed and rendering it ineffective.
Actionable advice:
Take Calcium-AKG at least 2 hours before or 4 hours after taking these antibiotics.
Target id:
/intervention/levothyroxine_systemic_disease
Target name:
Levothyroxine
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
4
Hours after target:
4
Description:
Calcium salts significantly decrease the absorption of levothyroxine from the gastrointestinal tract, which can lead to inadequate thyroid hormone levels and treatment failure.
Actionable advice:
Separate doses of Calcium-AKG and levothyroxine by at least 4 hours.
Target id:
/intervention/bisphosphonates
Target name:
Bisphosphonates (e.g., Alendronate)
Severity:
major
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
2
Description:
Calcium binds to bisphosphonate drugs in the gut, dramatically reducing their absorption and effectiveness in treating bone density loss. Bisphosphonates must be taken on an empty stomach.
Actionable advice:
Take Calcium-AKG at least 2 hours after your bisphosphonate dose.
Target id:
/condition/renal-impairment
Target name:
Renal Impairment / Kidney Disease
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Impaired kidneys cannot effectively regulate blood calcium levels, making supplementation risky and increasing the likelihood of dangerous hypercalcemia and soft tissue calcification.
Actionable advice:
Avoid using Calcium-AKG unless specifically directed and monitored by a nephrologist.
Target id:
/condition/hypercalcemia
Target name:
Hypercalcemia (High Blood Calcium)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Supplementing with calcium when blood calcium levels are already high will worsen the condition, increasing risks of kidney stones, cardiac issues, and cognitive changes.
Actionable advice:
Do not take Calcium-AKG if you have a history of or current hypercalcemia.
Target id:
/intervention/digoxin
Target name:
Digoxin
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
High blood calcium levels (hypercalcemia), which can be caused by calcium supplementation, increase the effects of digoxin on the heart, raising the risk of serious digoxin toxicity.
Actionable advice:
Avoid high-dose calcium supplements and consult your cardiologist before using Calcium-AKG.
Target id:
/class/diuretics
Target name:
Thiazide Diuretics (e.g., Hydrochlorothiazide)
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Thiazide diuretics decrease the amount of calcium excreted in the urine. When combined with calcium supplements, this can lead to excessively high levels of calcium in the blood (hypercalcemia).
Actionable advice:
Consult your doctor before combining; regular monitoring of blood calcium levels is required.
Target id:
/intervention/iron-bisglycinate
Target name:
Iron Supplements
Severity:
moderate
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
Calcium and non-heme iron compete for the same absorption pathways in the small intestine, leading to significantly reduced absorption of iron when taken together.
Actionable advice:
Separate doses of Calcium-AKG and iron supplements by at least 2 hours.
Target id:
/intervention/vitamin_d3_systemic_healthspan
Target name:
Vitamin D
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin D is essential for the absorption of calcium from the gut into the bloodstream. Without adequate Vitamin D, calcium supplementation is less effective and potentially riskier.
Actionable advice:
Ensure adequate Vitamin D levels through sun, diet, or supplements when taking Calcium-AKG.
Target id:
/intervention/vitamin-k2
Target name:
Vitamin K2
Severity:
moderate
Interaction type:
requirement
Nature:
absolute
Temporal spacing:
null
Description:
Vitamin K2 activates proteins that help direct absorbed calcium into bones and teeth and away from arteries and soft tissues, which is critical for cardiovascular and skeletal health.
Actionable advice:
Co-supplementation with Vitamin K2 is strongly recommended to ensure proper calcium utilization.
Target id:
/biomarker/serum-calcium
Target name:
Serum Calcium Levels
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Long-term supplementation with any calcium salt can potentially elevate serum calcium levels above the normal range, a condition known as hypercalcemia, which requires medical attention.
Actionable advice:
Periodically monitor serum calcium levels with your doctor when taking Calcium-AKG long-term.
Target id:
/class/dmt1-competing-minerals
Target name:
Other Divalent Minerals (Zinc, Magnesium)
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
2
Hours after target:
2
Description:
High doses of calcium can compete with other minerals like zinc and magnesium for absorption in the gut, potentially reducing their bioavailability if taken at the same time.
Actionable advice:
For optimal absorption, separate Calcium-AKG from zinc or magnesium supplements by 2 hours.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
diminishing
Nature:
temporal
Temporal spacing:
Hours before target:
1
Hours after target:
2
Description:
Meals high in phytates (grains, legumes) or oxalates (spinach) can bind to calcium, reducing its absorption. Taking it on an empty stomach may ensure maximal absorption of the AKG component.
Actionable advice:
Take on an empty stomach, at least 1 hour before or 2 hours after a meal.
Target id:
/dietary/fasting-state
Target name:
Fasted State
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Alpha-ketoglutarate may activate cellular pathways similar to those engaged during fasting (e.g., AMPK). Taking it in a fasted state could theoretically enhance its longevity-related benefits.
Actionable advice:
Take your daily dose in the morning while in a fasted state for potential synergistic effects.
Target id:
/class/calcium-channel-blockers
Target name:
Calcium Channel Blockers
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
Theoretically, very high levels of supplemental calcium could compete with calcium channel blocker medications at their site of action, potentially reducing their effectiveness in lowering blood pressure.
Actionable advice:
Monitor blood pressure if taking high doses of Calcium-AKG with these medications.