Meta Information

ID:calcium-akg

Name:Calcium Alpha-Ketoglutarate

Schema Version:1.5

Title

Calcium Alpha-Ketoglutarate

Alternate Names

• Ca-AKG
• CaAKG

Intervention Type

therapeutic_agent

Expected Cost Mean

Low Cost:

40

High Cost:

80

Cost Type:

monthly

Description:

Cost for a 30-day supply at a typical 1000mg daily dose.

Summary

Alpha-ketoglutarate (AKG) is a crucial molecule in the Krebs cycle, central to cellular energy production and metabolism. Its levels decline significantly with age, and supplementation may support metabolic function, act as an ammonia scavenger, and potentially influence epigenetic regulation by serving as a cofactor for TET enzymes.

Purpose

A metabolic intermediate that may support cellular energy and epigenetic health.

Card Summary

A key metabolic intermediate that declines with age, potentially supporting cellular energy and epigenetic regulation.

Drug Class

calcium

Drugs In Class

Empty Array

Impact

Score:

3.5

Justification:

Promising mouse data but lacks robust human lifespan or healthspan evidence.

Evidence

Grade:

C

Score:

3

Justification:

Strong lifespan/healthspan results in mice; human data is currently limited and observational.

Safety

Score:

3

Justification:

Generally Recognized As Safe (GRAS) substance with a good short-term safety profile.

Flags

• Human evidence is based on a single, non-placebo-controlled, retrospective study.
• High doses contribute significant calcium, a consideration for those with kidney issues.
• Supplement quality and purity can vary significantly between manufacturers.

Verdict

Promising in mice, but awaits confirmation from human clinical trials.

Created

2026-04-23T22:57:51.492026Z

Model

Gemini 3.1 Pro (High)

Delivery

Route:

oral

Scope:

• systemic

Indication

Focus:

healthspan

Description:

Alpha-ketoglutarate (AKG) is a crucial molecule in the Krebs cycle, central to cellular energy production and metabolism. Its levels decline significantly with age, and supplementation may support met...

Typical Protocol

• Take 1000 mg daily, often split into two doses with or without food.