Meta Information
ID:boron
Name:
Schema Version:AIM-2.0
Interactions
Target id:
/condition/renal-impairment
Target name:
Renal Impairment
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Boron is primarily excreted by the kidneys. Impaired renal function can lead to the accumulation of boron to potentially toxic levels.
Actionable advice:
Avoid boron supplementation if you have moderate to severe kidney disease, unless specifically approved by a nephrologist.
Target id:
/condition/pregnancy
Target name:
Pregnancy
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
The safety of boron supplementation during pregnancy has not been established, and high intake may pose risks to fetal development.
Actionable advice:
Do not take boron supplements during pregnancy.
Target id:
/condition/lactation
Target name:
Breastfeeding (Lactation)
Severity:
major
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
It is unknown if supplemental boron is excreted in breast milk or what its effects on a nursing infant might be. Due to a lack of safety data, it should be avoided.
Actionable advice:
Do not take boron supplements while breastfeeding.
Target id:
/condition/hormone-sensitive-cancers
Target name:
Hormone-Sensitive Cancers or Conditions
Severity:
moderate
Interaction type:
adverse
Nature:
absolute
Temporal spacing:
null
Description:
Boron can increase levels of steroid hormones like estrogen and testosterone, which could theoretically stimulate the growth of hormone-sensitive tissues.
Actionable advice:
Consult your oncologist or physician before using boron if you have a history of breast, uterine, ovarian, or prostate cancer, or conditions like endometriosis.
Target id:
/intervention/vitamin_d3_systemic_healthspan
Target name:
Vitamin D
Severity:
moderate
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Boron extends the half-life and increases the biological activity of Vitamin D, enhancing its effects on calcium metabolism and bone health.
Actionable advice:
Taking boron can improve the effectiveness of your Vitamin D supplementation; they can be taken at the same time.
Target id:
/biomarker/comprehensive-sex-hormone-panel
Target name:
Sex Hormone Panel (Testosterone, Estradiol, SHBG)
Severity:
moderate
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
null
Description:
Boron supplementation can physiologically alter hormone levels, notably increasing free testosterone and estradiol while decreasing Sex Hormone-Binding Globulin (SHBG). This is a true biological effect, not a direct chemical interference with the lab test.
Actionable advice:
Inform your physician that you are taking boron when interpreting sex hormone lab results, as it can significantly alter them.
Target id:
/intervention/magnesium
Target name:
Magnesium
Severity:
minor
Interaction type:
synergistic
Nature:
absolute
Temporal spacing:
null
Description:
Boron reduces the urinary excretion of magnesium, which can help the body retain this essential mineral, supporting bone and metabolic health.
Actionable advice:
Consider taking boron and magnesium together to support overall mineral status.
Target id:
/intervention/riboflavin
Target name:
Riboflavin (Vitamin B2)
Severity:
minor
Interaction type:
diminishing
Nature:
absolute
Temporal spacing:
null
Description:
High doses of boron can form a complex with riboflavin, increasing its excretion in the urine. This may lead to a depletion of riboflavin with long-term, high-dose boron use.
Actionable advice:
If taking high doses of boron (>10mg/day) long-term, ensure adequate riboflavin intake from diet or a B-complex supplement.
Target id:
/dietary/meal
Target name:
Any Caloric Meal
Severity:
minor
Interaction type:
synergistic
Nature:
temporal
Temporal spacing:
Hours before target:
0
Hours after target:
0
Description:
While boron is well-absorbed on an empty stomach, taking it with food can help prevent potential mild gastrointestinal discomfort in sensitive individuals.
Actionable advice:
Take boron with a meal to minimize any potential for stomach upset.
Target id:
/biomarker/vitamin-d
Target name:
25-OH Vitamin D
Severity:
minor
Interaction type:
assay_interference
Nature:
absolute
Temporal spacing:
null
Description:
By increasing the half-life and activity of Vitamin D, boron supplementation may lead to higher measured levels of 25-hydroxyvitamin D in the blood.
Actionable advice:
Be aware that your measured Vitamin D levels may be higher as a result of boron supplementation.